Five negative symptom domains are differentially associated with resting state amplitude of low frequency fluctuations in Schizophrenia.
Psychiatry Res Neuroimaging
; 329: 111597, 2023 03.
Article
em En
| MEDLINE
| ID: mdl-36680843
ABSTRACT
This study examined associations between resting-state amplitude of low frequency fluctuations (ALFF) and negative symptoms represented by total scores, second-order dimension (motivation and pleasure, expressivity), and first-order domain (anhedonia, avolition, asociality, alogia, blunted affect) factor scores in schizophrenia (n = 57). Total negative symptom scores showed positive associations with ALFF in temporal and frontal brain regions. Negative symptom domain scores showed predominantly stronger associations with regional ALFF compared to total scores, suggesting domain scores may better map to neural signatures than total scores. Improving our understanding of the neuropathology underlying negative symptoms may aid in addressing this unmet therapeutic need in schizophrenia.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Esquizofrenia
Tipo de estudo:
Diagnostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article