Hybrids of polyphenolic/quinone acids, the potential preventive and therapeutic drugs for PD: Disaggregate &#945;-Syn fibrils, inhibit inclusions, and repair damaged neurons in mice.

Lü, Ming-Huan; Wang, Zhen-Ping; Xing, Li-Zi; Zhang, Wei; Han, Feng; Huang, Guo-Long; Liu, Wei; Zhang, Yun-Xiao; Xu, Ji; Cui, Jinquan

Hybrids of polyphenolic/quinone acids, the potential preventive and therapeutic drugs for PD: Disaggregate α-Syn fibrils, inhibit inclusions, and repair damaged neurons in mice.

Lü, Ming-Huan; Wang, Zhen-Ping; Xing, Li-Zi; Zhang, Wei; Han, Feng; Huang, Guo-Long; Liu, Wei; Zhang, Yun-Xiao; Xu, Ji; Cui, Jinquan.

Afiliação

Lü MH; Green Catalysis Center, College of Chemistry, Zhengzhou University, Daxue Road 75, Zhengzhou, 450052, China; Department of Obstetrics and Gynecology, The Second Affiliated Hospital, Zhengzhou University, Zhengzhou, 450014, China.
Wang ZP; Green Catalysis Center, College of Chemistry, Zhengzhou University, Daxue Road 75, Zhengzhou, 450052, China.
Xing LZ; Green Catalysis Center, College of Chemistry, Zhengzhou University, Daxue Road 75, Zhengzhou, 450052, China.
Zhang W; Green Catalysis Center, College of Chemistry, Zhengzhou University, Daxue Road 75, Zhengzhou, 450052, China.
Han F; Green Catalysis Center, College of Chemistry, Zhengzhou University, Daxue Road 75, Zhengzhou, 450052, China.
Huang GL; Green Catalysis Center, College of Chemistry, Zhengzhou University, Daxue Road 75, Zhengzhou, 450052, China.
Liu W; Green Catalysis Center, College of Chemistry, Zhengzhou University, Daxue Road 75, Zhengzhou, 450052, China.
Zhang YX; Green Catalysis Center, College of Chemistry, Zhengzhou University, Daxue Road 75, Zhengzhou, 450052, China. Electronic address: zhangyx@zzu.edu.cn.
Xu J; School of Basic Medical Science, Neuroscience Research Institute, Academy of Medical Sciences, Zhengzhou University, Kexue Road 100, Zhengzhou, 45000, China. Electronic address: xuji@zzu.edu.cn.
Cui J; Department of Obstetrics and Gynecology, The Second Affiliated Hospital, Zhengzhou University, Zhengzhou, 450014, China. Electronic address: jinquan_cui@163.com.

Eur J Med Chem ; 249: 115122, 2023 Mar 05.

Article em En | MEDLINE | ID: mdl-36680987

Assuntos

Doença de Parkinson; Camundongos; Animais; Cavalos; Doença de Parkinson/tratamento farmacológico; alfa-Sinucleína; Corpos de Lewy; Neurônios; Benzoquinonas

Palavras-chave

Inclusions; Neurons repair; Parkinson's disease; Protein disaggregation; α-Syn aggregation inhibition

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo

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XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article