Abcc8 (sulfonylurea receptor-1) knockout mice exhibit reduced axonal injury, cytotoxic edema and cognitive dysfunction vs. wild-type in a cecal ligation and puncture model of sepsis.

Cummings, Jessica; Wu, Yijen L; Dixon, C Edward; Henchir, Jeremy; Simard, J Marc; Panigrahy, Ashok; Kochanek, Patrick M; Jha, Ruchira M; Aneja, Rajesh K

Cummings, Jessica; Wu, Yijen L; Dixon, C Edward; Henchir, Jeremy; Simard, J Marc; Panigrahy, Ashok; Kochanek, Patrick M; Jha, Ruchira M; Aneja, Rajesh K.

Afiliação

Cummings J; Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Wu YL; Department of Developmental Biology, University of Pittsburgh, Pittsburgh, PA, USA.
Dixon CE; Department of Neurosurgery, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Henchir J; Division of Pediatric Critical Care Medicine, Safar Center for Resuscitation Research, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA.
Simard JM; Division of Pediatric Critical Care Medicine, Safar Center for Resuscitation Research, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA.
Panigrahy A; Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, USA.
Kochanek PM; Division of Pediatric Radiology, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.
Jha RM; Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Aneja RK; Division of Pediatric Critical Care Medicine, Safar Center for Resuscitation Research, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA.

J Neuroinflammation ; 20(1): 12, 2023 Jan 21.

Article em En | MEDLINE | ID: mdl-36681815

Assuntos

Antineoplásicos; Edema Encefálico; Lesões Encefálicas; Disfunção Cognitiva; Sepse; Canais de Cátion TRPM; Camundongos; Masculino; Animais; Camundongos Knockout; Receptores de Sulfonilureias/genética; Edema Encefálico/genética; Sepse/complicações; Sepse/genética; Sepse/patologia; Lesões Encefálicas/complicações; Punções; Edema; Ligadura; Camundongos Endogâmicos C57BL

Palavras-chave

Axonal injury; Cecal ligation and puncture; Cytotoxic edema; Microglial activation; Sepsis; Sulfonylurea receptor 1 (SUR1, Abcc8); Transient receptor potential melastatin 4 (TRPM4)

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Edema Encefálico / Lesões Encefálicas / Sepse / Canais de Cátion TRPM / Disfunção Cognitiva / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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