Structure optimization, synthesis, and biological evaluation of 6-(2-amino-1H-benzo[d]imidazole-6-yl)-quinazolin-4(3H)-one derivatives as potential multi-targeted anticancer agents via Aurora A/ PI3K/BRD4 inhibition.

Fan, Yanhua; Luo, Fang; Su, Mingzhi; Li, Qing; Zhong, Ting; Xiong, Liang; Li, Mei; Yuan, Meitao; Wang, Daoping

Fan, Yanhua; Luo, Fang; Su, Mingzhi; Li, Qing; Zhong, Ting; Xiong, Liang; Li, Mei; Yuan, Meitao; Wang, Daoping.

Afiliação

Fan Y; State Key Laboratory for Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China; The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550014, China.
Luo F; State Key Laboratory for Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China; The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550014, China. Electronic address: 17810259289@163.com.
Su M; State Key Laboratory for Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China; The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550014, China.
Li Q; State Key Laboratory for Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China; The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550014, China.
Zhong T; State Key Laboratory for Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China; The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550014, China.
Xiong L; State Key Laboratory for Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China; The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550014, China.
Li M; State Key Laboratory for Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China; The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550014, China.
Yuan M; State Key Laboratory for Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China; The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550014, China.
Wang D; State Key Laboratory for Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China; The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550014, China.

Bioorg Chem ; 132: 106352, 2023 03.

Article em En | MEDLINE | ID: mdl-36682147

Assuntos

Antineoplásicos; Carcinoma Pulmonar de Células não Pequenas; Neoplasias Pulmonares; Humanos; Relação Estrutura-Atividade; Fosfatidilinositol 3-Quinases/metabolismo; Proteínas Nucleares/metabolismo; Carcinoma Pulmonar de Células não Pequenas/tratamento farmacológico; Inibidores de Proteínas Quinases; Aurora Quinase A/metabolismo; Aurora Quinase A/farmacologia; Fatores de Transcrição; Antineoplásicos/química; Proliferação de Células; Imidazóis/farmacologia; Linhagem Celular Tumoral; Ensaios de Seleção de Medicamentos Antitumorais; Estrutura Molecular

Palavras-chave

Aurora A; BRD4; Multi-targeted inhibitor; Non-small cell lung cancer; PI3Kα; Quinazolin-4(3H)-one moiety; Structure optimization

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carcinoma Pulmonar de Células não Pequenas / Neoplasias Pulmonares / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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