A novel micropattern platform constructed by TiO2 oxidation of PDA.
Colloids Surf B Biointerfaces
; 223: 113141, 2023 Mar.
Article
em En
| MEDLINE
| ID: mdl-36682296
ABSTRACT
Dopamine is a small molecule inspired by the dopamine motif of mussel foot proteins, and PDA is formed by the self-polymerization of dopamine. Under the UV-irradiationï¼PDA would be oxidized by reactive oxygen species (ROS) which were produced by photocatalytic reactions on TiO2 surfacesï¼thus regulating the adhesion behavior of endothelial cells (ECs) TiO2 inhibited platelet (Plt) adhesion after UV exposure. Polydopamine (PDA)-TiO2 micropatterns (P-PDA-TiO2) were prepared by magnetron sputtering and photolithography. This micropatterns successfully achieves selective adhesion of Plt and ECs. The selective adhesion of ECs disappears after vacuum reduction. In contrast to conventional cell patterning strategies, P-PDA-TiO2 can easily achieve pattern separation of ECs and Plts and provide a new concept for building complex blood-contacting devices.
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Base de dados:
MEDLINE
Assunto principal:
Dopamina
/
Células Endoteliais
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article