Synthesis of 1-O-acyl- and 1-oxo-kamebanin analogues and their cytotoxic activity.
Bioorg Med Chem Lett
; 82: 129149, 2023 02 15.
Article
em En
| MEDLINE
| ID: mdl-36690039
ABSTRACT
A series of 1-O-acyl- and 1-oxo-kamebanin analogues were prepared from kamebanin, isolated from Rabdosia excisa and their cytotoxicity was assayed on HL60 promyelocytic leukemia cells and HCT116 human colon cancer cells. The structure-activity relationship study showed that the presence of 1-O-acyl groups of a C3-C5 carbon chain increased the cytotoxic activity.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Isodon
/
Antineoplásicos
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article