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Synthesis of 1-O-acyl- and 1-oxo-kamebanin analogues and their cytotoxic activity.
Aoyagi, Yutaka; Tomita, Kaori; Kobayashi, Asumi; Nakamura, Akari; Fujii, Yuki; Yagi, Momoka; Ichimaru, Yoshimi; Ozawa, Kei; Park, Hyun-Sun; Fukaya, Haruhiko; Yano, Reiko; Hasuda, Tomoyo; Takeya, Koichi; Hitotsuyanagi, Yukio; Gui, Ming-Yu; Jin, Yong-Ri; Li, Xu-Wen.
Afiliação
  • Aoyagi Y; College of Pharmacy, Kinjo Gakuin University, 2-1723 Omori, Moriyama-ku, Nagoya, Aich 463-8521, Japan. Electronic address: yutaka@kinjo-u.ac.jp.
  • Tomita K; College of Pharmacy, Kinjo Gakuin University, 2-1723 Omori, Moriyama-ku, Nagoya, Aich 463-8521, Japan.
  • Kobayashi A; College of Pharmacy, Kinjo Gakuin University, 2-1723 Omori, Moriyama-ku, Nagoya, Aich 463-8521, Japan.
  • Nakamura A; College of Pharmacy, Kinjo Gakuin University, 2-1723 Omori, Moriyama-ku, Nagoya, Aich 463-8521, Japan.
  • Fujii Y; College of Pharmacy, Kinjo Gakuin University, 2-1723 Omori, Moriyama-ku, Nagoya, Aich 463-8521, Japan.
  • Yagi M; College of Pharmacy, Kinjo Gakuin University, 2-1723 Omori, Moriyama-ku, Nagoya, Aich 463-8521, Japan.
  • Ichimaru Y; College of Pharmacy, Kinjo Gakuin University, 2-1723 Omori, Moriyama-ku, Nagoya, Aich 463-8521, Japan.
  • Ozawa K; 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
  • Park HS; 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
  • Fukaya H; 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
  • Yano R; College of Pharmacy, Kinjo Gakuin University, 2-1723 Omori, Moriyama-ku, Nagoya, Aich 463-8521, Japan.
  • Hasuda T; 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
  • Takeya K; 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
  • Hitotsuyanagi Y; 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan. Electronic address: yukioh@toyalu.ac.jp.
  • Gui MY; Department of Chemistry, JiLin University, No. 2 Xinmin street, Changchun, JiLin 130021, China.
  • Jin YR; Department of Chemistry, JiLin University, No. 2 Xinmin street, Changchun, JiLin 130021, China.
  • Li XW; Department of Chemistry, JiLin University, No. 2 Xinmin street, Changchun, JiLin 130021, China.
Bioorg Med Chem Lett ; 82: 129149, 2023 02 15.
Article em En | MEDLINE | ID: mdl-36690039
ABSTRACT
A series of 1-O-acyl- and 1-oxo-kamebanin analogues were prepared from kamebanin, isolated from Rabdosia excisa and their cytotoxicity was assayed on HL60 promyelocytic leukemia cells and HCT116 human colon cancer cells. The structure-activity relationship study showed that the presence of 1-O-acyl groups of a C3-C5 carbon chain increased the cytotoxic activity.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Isodon / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Isodon / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article