Neurofilament light chain and dorsal root ganglia injury after adeno-associated virus 9 gene therapy in nonhuman primates.

Johnson, Eric W; Sutherland, Jeffrey J; Meseck, Emily; McElroy, Cameron; Chand, Deepa H; Tukov, Francis Fonyuy; Hudry, Eloise; Penraat, Kelley

Johnson, Eric W; Sutherland, Jeffrey J; Meseck, Emily; McElroy, Cameron; Chand, Deepa H; Tukov, Francis Fonyuy; Hudry, Eloise; Penraat, Kelley.

Afiliação

Johnson EW; Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA.
Sutherland JJ; Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA.
Meseck E; Novartis Pharmaceuticals Corporation, East Hanover, NJ 07936, USA.
McElroy C; Novartis Pharmaceuticals Corporation, East Hanover, NJ 07936, USA.
Chand DH; Novartis Pharmaceuticals Corporation, East Hanover, NJ 07936, USA.
Tukov FF; University of Illinois College of Medicine-Peoria, Children's Hospital of Illinois, Peoria IL 61605, USA.
Hudry E; Novartis Pharmaceuticals Corporation, East Hanover, NJ 07936, USA.
Penraat K; Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA.

Mol Ther Methods Clin Dev ; 28: 208-219, 2023 Mar 09.

Article em En | MEDLINE | ID: mdl-36700120

Palavras-chave

adeno-associated virus 9 gene therapy; cerebrospinal fluid; dorsal root ganglia toxicity; dorsal root ganglia/trigeminal ganglia pathology; neurofilament light chain; nonclinical toxicology; nonhuman primates; peripheral neuropathy; sensory neuropathy; soluble biomarkers

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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Risk_factors_studies Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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PubMed Links

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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Risk_factors_studies Idioma: En Ano de publicação: 2023 Tipo de documento: Article