Repositioning of simvastatin for diabetic colon cancer: role of CDK4 inhibition and apoptosis.

Gajjar, Saumitra; Bora, Vivek; Patel, Bhoomika M

Gajjar, Saumitra; Bora, Vivek; Patel, Bhoomika M.

Afiliação

Gajjar S; Institute of Pharmacy, Nirma University, Sarkhej-Gandhinagar Highway, Ahmedabad, Gujarat, 382 481, India.
Bora V; Institute of Pharmacy, Nirma University, Sarkhej-Gandhinagar Highway, Ahmedabad, Gujarat, 382 481, India.
Patel BM; National Forensic Sciences University, Gandhinagar, India. drbhoomikampatel@gmail.com.

Mol Cell Biochem ; 478(10): 2337-2349, 2023 Oct.

Article em En | MEDLINE | ID: mdl-36703094

Assuntos

Neoplasias do Colo; Diabetes Mellitus Tipo 2; Masculino; Animais; Humanos; Feminino; Sinvastatina/farmacologia; Reposicionamento de Medicamentos; Neoplasias do Colo/metabolismo; Apoptose; Linhagem Celular Tumoral; Quinase 4 Dependente de Ciclina/genética

Palavras-chave

1,2 Dimethylhydrazine; Annexin V-FITC; CDK4; Streptozotocin; Therapeutic switching

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias do Colo / Diabetes Mellitus Tipo 2 Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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