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Habituation of the stress response multiplex to repeated cold pressor exposure.
Bullock, Tom; MacLean, Mary H; Santander, Tyler; Boone, Alexander P; Babenko, Viktoriya; Dundon, Neil M; Stuber, Alexander; Jimmons, Liann; Raymer, Jamie; Okafor, Gold N; Miller, Michael B; Giesbrecht, Barry; Grafton, Scott T.
Afiliação
  • Bullock T; Department of Psychological and Brain Sciences, University of California, Santa Barbara, Santa Barbara, CA, United States.
  • MacLean MH; Institute for Collaborative Biotechnologies, University of California, Santa Barbara, Santa Barbara, CA, United States.
  • Santander T; Department of Psychological and Brain Sciences, University of California, Santa Barbara, Santa Barbara, CA, United States.
  • Boone AP; Institute for Collaborative Biotechnologies, University of California, Santa Barbara, Santa Barbara, CA, United States.
  • Babenko V; Department of Psychological and Brain Sciences, University of California, Santa Barbara, Santa Barbara, CA, United States.
  • Dundon NM; Institute for Collaborative Biotechnologies, University of California, Santa Barbara, Santa Barbara, CA, United States.
  • Stuber A; Department of Psychological and Brain Sciences, University of California, Santa Barbara, Santa Barbara, CA, United States.
  • Jimmons L; Department of Psychological and Brain Sciences, University of California, Santa Barbara, Santa Barbara, CA, United States.
  • Raymer J; Institute for Collaborative Biotechnologies, University of California, Santa Barbara, Santa Barbara, CA, United States.
  • Okafor GN; Department of Psychological and Brain Sciences, University of California, Santa Barbara, Santa Barbara, CA, United States.
  • Miller MB; Institute for Collaborative Biotechnologies, University of California, Santa Barbara, Santa Barbara, CA, United States.
  • Giesbrecht B; Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics, University of Freiburg, Freiburg im Breisgau, Germany.
  • Grafton ST; Department of Psychological and Brain Sciences, University of California, Santa Barbara, Santa Barbara, CA, United States.
Front Physiol ; 13: 752900, 2022.
Article em En | MEDLINE | ID: mdl-36703933
ABSTRACT
Humans show remarkable habituation to aversive events as reflected by changes of both subjective report and objective measures of stress. Although much experimental human research focuses on the effects of stress, relatively little is known about the cascade of physiological and neural responses that contribute to stress habituation. The cold pressor test (CPT) is a common method for inducing acute stress in human participants in the laboratory; however, there are gaps in our understanding of the global state changes resulting from this stress-induction technique and how these responses change over multiple exposures. Here, we measure the stress response to repeated CPT exposures using an extensive suite of physiologic measures and state-of-the-art analysis techniques. In two separate sessions on different days, participants underwent five 90 s CPT exposures of both feet and five warm water control exposures, while electrocardiography (ECG), impedance cardiography, continuous blood pressure, pupillometry, scalp electroencephalography (EEG), salivary cortisol and self-reported pain assessments were recorded. A diverse array of adaptive responses are reported that vary in their temporal dynamics within each exposure as well as habituation across repeated exposures. During cold-water exposure there was a cascade of changes across several cardiovascular measures (elevated heart rate (HR), cardiac output (CO) and Mean Arterial Pressure (MAP) and reduced left ventricular ejection time (LVET), stroke volume (SV) and high-frequency heart rate variability (HF)). Increased pupil dilation was observed, as was increased power in low-frequency bands (delta and theta) across frontal EEG electrode sites. Several cardiovascular measures also habituated over repeated cold-water exposures (HR, MAP, CO, SV, LVET) as did pupil dilation and alpha frequency activity across the scalp. Anticipation of cold water induced stress effects in the time-period immediately prior to exposure, indexed by increased pupil size and cortical disinhibition in the alpha and beta frequency bands across central scalp sites. These results provide comprehensive insight into the evolution of a diverse array of stress responses to an acute noxious stressor, and how these responses adaptively contribute to stress habituation.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article