Hypoxia-sensitive miRNA regulation <i>via</i> CRISPR/dCas9 loaded in hybrid exosomes: A novel strategy to improve embryo implantation and prevent placental insufficiency during pregnancy.

Yaghoobi, Alireza; Nazerian, Yasaman; Meymand, Arman Zeinaddini; Ansari, Ali; Nazerian, Amirhossein; Niknejad, Hassan

Hypoxia-sensitive miRNA regulation via CRISPR/dCas9 loaded in hybrid exosomes: A novel strategy to improve embryo implantation and prevent placental insufficiency during pregnancy.

Yaghoobi, Alireza; Nazerian, Yasaman; Meymand, Arman Zeinaddini; Ansari, Ali; Nazerian, Amirhossein; Niknejad, Hassan.

Afiliação

Yaghoobi A; Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Nazerian Y; Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Meymand AZ; Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Ansari A; Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Nazerian A; School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Niknejad H; Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Front Cell Dev Biol ; 10: 1082657, 2022.

Article em En | MEDLINE | ID: mdl-36704201

Palavras-chave

CRISPR/dCas9; HIF-1α; endometrial receptivity; infertility; liposomeexosome hybrid; mir-30d; recurrent implantation failure; regenerative medicine

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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies Idioma: En Ano de publicação: 2022 Tipo de documento: Article