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A Moving Target: Impacts of Lowering Viral Load Suppression Cutpoints on Progress Towards HIV Epidemic Control Goals.
Rosen, Joseph G; Reynolds, Steven J; Galiwango, Ronald M; Kigozi, Godfrey; Quinn, Thomas C; Ratmann, Oliver; Ndyanabo, Anthony; Nelson, Lisa J; Nakigozi, Gertrude; Nalugemwa, Margaret; Rucinski, Katherine B; Kennedy, Caitlin E; Chang, Larry W; Kagaayi, Joseph; Serwadda, David; Grabowski, M Kate.
Afiliação
  • Rosen JG; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
  • Reynolds SJ; Rakai Health Sciences Program, Entebbe, Uganda.
  • Galiwango RM; Division of Infectious Diseases, Johns Hopkins School of Medicine, Baltimore, MD, USA.
  • Kigozi G; Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
  • Quinn TC; Rakai Health Sciences Program, Entebbe, Uganda.
  • Ratmann O; Rakai Health Sciences Program, Entebbe, Uganda.
  • Ndyanabo A; Rakai Health Sciences Program, Entebbe, Uganda.
  • Nelson LJ; Division of Infectious Diseases, Johns Hopkins School of Medicine, Baltimore, MD, USA.
  • Nakigozi G; Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
  • Nalugemwa M; Department of Mathematics, Imperial College, London, United Kingdom.
  • Rucinski KB; Rakai Health Sciences Program, Entebbe, Uganda.
  • Kennedy CE; Centers for Disease Control and Prevention, Kampala, Uganda.
  • Chang LW; Rakai Health Sciences Program, Entebbe, Uganda.
  • Kagaayi J; Rakai Health Sciences Program, Entebbe, Uganda.
  • Serwadda D; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
  • Grabowski MK; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
medRxiv ; 2023 Jan 20.
Article em En | MEDLINE | ID: mdl-36711720
Redefining viral load suppression (VLS) using lower cutpoints could impact progress towards the UNAIDS 95-95-95 targets. We assessed impacts of lowering the VLS cutpoint on achieving the 95-95-95 VLS target in the Rakai Community Cohort Study. Population VLS fell from 86% to 84% and 76%, respectively, after lowering VLS cutpoints from <1,000 to <200 and <50 copies/mL. The fraction of viremic persons increased by 17% after lowering the VLS cutpoint from <1,000 to <200 copies/mL.
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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Observational_studies Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Observational_studies Idioma: En Ano de publicação: 2023 Tipo de documento: Article