The Gcn5-Ada2-Ada3 histone acetyltransferase module has divergent roles in pathogenesis of Candida glabrata.

Lin, Chi-Jan; Yang, Sheng-Yung; Hsu, Li-Hang; Yu, Shang-Jie; Chen, Ying-Lien

Lin, Chi-Jan; Yang, Sheng-Yung; Hsu, Li-Hang; Yu, Shang-Jie; Chen, Ying-Lien.

Afiliação

Lin CJ; Institute of Molecular Biology, National Chung Hsing University, 40227 Taichung, Taiwan.
Yang SY; Department of Plant Pathology and Microbiology, National Taiwan University, 10617 Taipei, Taiwan.
Hsu LH; Department of Plant Pathology and Microbiology, National Taiwan University, 10617 Taipei, Taiwan.
Yu SJ; Department of Plant Pathology and Microbiology, National Taiwan University, 10617 Taipei, Taiwan.
Chen YL; Department of Plant Pathology and Microbiology, National Taiwan University, 10617 Taipei, Taiwan.

Med Mycol ; 61(2)2023 Feb 03.

Article em En | MEDLINE | ID: mdl-36715154

The present study characterizes the functions of the conserved histone acetyltransferase module in the pathogenesis of the pathogenic yeast Candida glabrata. The results indicated that this module has divergent roles in the pathogenesis of C. glabrata.

Assuntos

Candidíase; Proteínas de Saccharomyces cerevisiae; Animais; Camundongos; Histona Acetiltransferases/genética; Histona Acetiltransferases/metabolismo; Candida glabrata/genética; Fatores de Transcrição/genética; Antifúngicos; Peróxido de Hidrogênio; Candidíase/veterinária; Proteínas de Saccharomyces cerevisiae/genética; Proteínas de Saccharomyces cerevisiae/metabolismo

Palavras-chave

Candida glabrata; SAGA complex; agar invasion; biofilm formation; oxidative stress; virulence

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Candidíase / Proteínas de Saccharomyces cerevisiae Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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