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K2S2O8-Mediated Radical Cyclization of 1,6-Enyne for the Synthesis of Diiodonated γ-Lactams.
Lu, Yuling; Zhang, Jiale; Duan, Xianxian; Yang, Boyi; Zhao, Chunhua; Gu, Lianghu; Chen, Chunmei; Zhu, Hucheng; Ye, Ying; Luo, Zengwei; Zhang, Yonghui.
Afiliação
  • Lu Y; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation. School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, P. R. of China.
  • Zhang J; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation. School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, P. R. of China.
  • Duan X; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation. School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, P. R. of China.
  • Yang B; Department of Forensic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
  • Zhao C; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation. School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, P. R. of China.
  • Gu L; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation. School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, P. R. of China.
  • Chen C; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation. School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, P. R. of China.
  • Zhu H; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation. School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, P. R. of China.
  • Ye Y; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation. School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, P. R. of China.
  • Luo Z; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation. School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, P. R. of China.
  • Zhang Y; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation. School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, P. R. of China.
J Org Chem ; 88(4): 2393-2403, 2023 Feb 17.
Article em En | MEDLINE | ID: mdl-36715636
ABSTRACT
A novel and convenient K2S2O8-mediated diiodo cyclization of 1,6-enynes for the facile synthesis of functionalized γ-lactam derivatives has been developed. This reaction features mild and transition-metal-free conditions, which offer a green and efficient entry to synthetically important γ-lactam scaffolds. Mechanistic studies suggest that iodide radicals initiate the cascade cyclic transformation.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article