Hypolypidemic Activity of L-Rhamnopyranosyl-6-O-Methyl-D-Galacturonan, a Polysaccharide Isolated from Birch Leaves (Betula pendula L.).
Bull Exp Biol Med
; 174(3): 330-332, 2023 Jan.
Article
em En
| MEDLINE
| ID: mdl-36723740
ABSTRACT
In male Syrian hamsters fed a synthetic high-fat diet enriched with cholesterol (0.3%), administration of a polysaccharide from birch leaves L-rhamnopyranosyl-6-O-methyl-D-galacturonan (3 g/100 g of diet) resulted in a decrease in total cholesterol levels, mainly due to the LDL fraction, triglycerides, and bile acids in blood serum; the content of triglycerides and cholesterol in the liver also decreased, while excretion of bile acids with feces increased. Thus, the lipid-lowering effect of L-rhamnopyranosyl-6-O-methyl-D-galacturonan is related to its ability to bind bile acids in the intestine and interrupt their enterohepatic circulation.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Colesterol
/
Betula
Limite:
Animals
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article