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Identification of HSD17B12 as an enzyme catalyzing drug reduction reactions through investigation of nabumetone metabolism.
Ichida, Hiroyuki; Fukami, Tatsuki; Kudo, Takashi; Mishiro, Kenji; Takano, Shiori; Nakano, Masataka; Morinaga, Gaku; Matsui, Akiko; Ishiguro, Naoki; Nakajima, Miki.
Afiliação
  • Ichida H; Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Japan.
  • Fukami T; Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Japan; WPI Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, Kanazawa, Japan. Electronic address: tatsuki@p.kanazawa-u.ac.jp.
  • Kudo T; Pharmacokinetics and Non-Clinical Safety Department, Nippon Boehringer Ingelheim Co. Ltd., Kobe, Japan.
  • Mishiro K; Innovative Integrated Bio-Research Core, Institute for Frontier Science Initiative, Kanazawa University, Kanazawa, Japan.
  • Takano S; Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Japan.
  • Nakano M; Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Japan; WPI Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, Kanazawa, Japan.
  • Morinaga G; Pharmacokinetics and Non-Clinical Safety Department, Nippon Boehringer Ingelheim Co. Ltd., Kobe, Japan.
  • Matsui A; Pharmacokinetics and Non-Clinical Safety Department, Nippon Boehringer Ingelheim Co. Ltd., Kobe, Japan.
  • Ishiguro N; Pharmacokinetics and Non-Clinical Safety Department, Nippon Boehringer Ingelheim Co. Ltd., Kobe, Japan.
  • Nakajima M; Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Japan; WPI Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, Kanazawa, Japan.
Arch Biochem Biophys ; 736: 109536, 2023 03 01.
Article em En | MEDLINE | ID: mdl-36724833
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pentoxifilina Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pentoxifilina Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article