Direct Benzylic C-H Functionalization with Fluorenones under Visible-Light Irradiation.
J Org Chem
; 88(4): 2612-2620, 2023 Feb 17.
Article
em En
| MEDLINE
| ID: mdl-36725672
ABSTRACT
An external photocatalyst-free benzylic C-H functionalization with fluorenones under visible-light irradiation has been achieved. This transformation provides an efficient synthetic approach to 9-benzylated fluorenols in ≤91% yield with 100% atom economy under mild conditions. Spectroscopic studies suggest that a reductive quenching of photoexcited fluorenones with toluene derivatives generates ketyl radicals and benzyl radicals, which undergo a cross-coupling to afford the desired fluorenols.
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Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2023
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Article