Design, synthesis and cytotoxic evaluation of novel bis-thiazole derivatives as preferential Pim1 kinase inhibitors with <i>in vivo</i> and <i>in silico</i> study.

Al-Sanea, Mohammad M; Nasr, Tamer M; Bondock, Samir; Gawish, Aya Y; Mohamed, Nada M

Design, synthesis and cytotoxic evaluation of novel bis-thiazole derivatives as preferential Pim1 kinase inhibitors with in vivo and in silico study.

Al-Sanea, Mohammad M; Nasr, Tamer M; Bondock, Samir; Gawish, Aya Y; Mohamed, Nada M.

Afiliação

Al-Sanea MM; Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka, Saudi Arabia.
Nasr TM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Modern University for Technology and Information (MTI) University, Cairo, Egypt.
Bondock S; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Helwan University, Helwan, Egypt.
Gawish AY; Chemistry Department, Faculty of Science, King Khalid University, Abha, Saudi Arabia.
Mohamed NM; Chemistry Department, Faculty of Science, Mansoura University, Mansoura, Egypt.

J Enzyme Inhib Med Chem ; 38(1): 2166936, 2023 Dec.

Article em En | MEDLINE | ID: mdl-36728746

Assuntos

Antineoplásicos; Tiazóis; Tiazóis/farmacologia; Antineoplásicos/farmacologia; Ciclo Celular; Estaurosporina/farmacologia; Regulação para Cima; Proliferação de Células; Ensaios de Seleção de Medicamentos Antitumorais; Relação Estrutura-Atividade

Palavras-chave

Pim1 inhibitor; bis-thiazole; cytotoxicity; in silico and in vivo study

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tiazóis / Antineoplásicos Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tiazóis / Antineoplásicos Idioma: En Ano de publicação: 2023 Tipo de documento: Article