FIRE Mimics a 14-3-3-Binding Motif to Promote Phytophthora palmivora Infection.
Mol Plant Microbe Interact
; 36(6): 315-322, 2023 Jun.
Article
em En
| MEDLINE
| ID: mdl-36734982
ABSTRACT
The oomycete Phytophthora palmivora infects a wide range of tropical crops worldwide. Like other filamentous plant pathogens, it secretes effectors to colonize plant tissues. Here, we characterize FIRE, an RXLR effector that contains a canonical mode I 14-3-3 phospho-sensor-binding motif that is conserved in effectors of several Phytophthora species. FIRE is phosphorylated in planta and interacts with multiple 14-3-3 proteins. Binding is sensitive to the R18 14-3-3 inhibitor. FIRE promotes plant susceptibility and co-localizes with its target around haustoria. This work uncovers a new type of oomycete effector target mechanism. It demonstrates that substrate mimicry for 14-3-3 proteins is a cross-kingdom effector strategy used by both prokaryotic and eukaryotic plant pathogens to suppress host immunity. [Formula see text] Copyright © 2023 The Author(s). This is an open access article distributed under the CC BY 4.0 International license.
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MEDLINE
Assunto principal:
Phytophthora
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article