Mapping cryptic binding sites of drug targets to overcome drug resistance.

Gao, Yang-Yang; Yang, Wei-Cheng; Ashby, Charles R; Hao, Ge-Fei

Gao, Yang-Yang; Yang, Wei-Cheng; Ashby, Charles R; Hao, Ge-Fei.

Afiliação

Gao YY; National Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for Research and Development of Fine Chemicals, Guizhou University, Guiyang 550025, PR China.
Yang WC; National Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for Research and Development of Fine Chemicals, Guizhou University, Guiyang 550025, PR China.
Ashby CR; Department of Pharmaceutical Sciences, St. John's University, New York, NY, USA. Electronic address: cnsratdoc@optonline.net.
Hao GF; National Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for Research and Development of Fine Chemicals, Guizhou University, Guiyang 550025, PR China; Key Laboratory of Pesticide & Chemical Biology, Ministry of E

Drug Resist Updat ; 67: 100934, 2023 03.

Article em En | MEDLINE | ID: mdl-36736042

ABSTRACT

ABSTRACT

The emergence of drug resistance is a primary obstacle for successful chemotherapy. Drugs that target cryptic binding sites (CBSs) represent a novel strategy for overcoming drug resistance. In this short communication, we explain and discuss how the discovery of CBSs and their inhibitors can overcome drug resistance.

Assuntos

Resistencia a Medicamentos Antineoplásicos; Humanos; Sítios de Ligação

Palavras-chave

Cryptic binding sites; Drug resistance; Resistance management

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Resistencia a Medicamentos Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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