Sirt3 restricts tumor initiation via promoting LONP1 deacetylation and K63 ubiquitination.

Wu, Liyi; Yan, Xinyi; Sun, Ruibo; Ma, Ye; Yao, Wanyu; Gao, Baogui; Zhang, Qingyuan; You, Junxiong; Wang, Hao; Han, Qinrui; Sun, Xuegang

Wu, Liyi; Yan, Xinyi; Sun, Ruibo; Ma, Ye; Yao, Wanyu; Gao, Baogui; Zhang, Qingyuan; You, Junxiong; Wang, Hao; Han, Qinrui; Sun, Xuegang.

Afiliação

Wu L; The Key Laboratory of Molecular Biology, State Administration of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, Guangdong, China.
Yan X; The Key Laboratory of Molecular Biology, State Administration of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, Guangdong, China.
Sun R; The Key Laboratory of Molecular Biology, State Administration of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, Guangdong, China.
Ma Y; The Key Laboratory of Molecular Biology, State Administration of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, Guangdong, China.
Yao W; The Key Laboratory of Molecular Biology, State Administration of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, Guangdong, China.
Gao B; The Key Laboratory of Molecular Biology, State Administration of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, Guangdong, China.
Zhang Q; The Key Laboratory of Molecular Biology, State Administration of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, Guangdong, China.
You J; The Key Laboratory of Molecular Biology, State Administration of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, Guangdong, China.
Wang H; The Key Laboratory of Molecular Biology, State Administration of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, Guangdong, China.
Han Q; The Key Laboratory of Molecular Biology, State Administration of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, Guangdong, China. hanqinrui918@smu.edu.cn.
Sun X; The Key Laboratory of Molecular Biology, State Administration of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, Guangdong, China. sxg_smu@126.com.

J Transl Med ; 21(1): 81, 2023 02 04.

Article em En | MEDLINE | ID: mdl-36739437

Assuntos

Neoplasias; Protease La; Sirtuína 3; Animais; Humanos; Camundongos; Acetilação; Proteases Dependentes de ATP/genética; Proteases Dependentes de ATP/metabolismo; Transformação Celular Neoplásica; Proteínas Mitocondriais/genética; Protease La/genética; Protease La/metabolismo; Sirtuína 3/metabolismo; Ubiquitinação

Palavras-chave

Deacetylation; Energy metabolism; LONP1; Oncogenesis; Sirt3; Ubiquitination

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Protease La / Sirtuína 3 / Neoplasias Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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