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Distinguishing apathy from depression: A review differentiating the behavioral, neuroanatomic, and treatment-related aspects of apathy from depression in neurocognitive disorders.
Lanctôt, Krista L; Ismail, Zahinoor; Bawa, Kritleen K; Cummings, Jeffrey L; Husain, Masud; Mortby, Moyra E; Robert, Philippe.
Afiliação
  • Lanctôt KL; Departments of Psychiatry and of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada.
  • Ismail Z; Neuropsychopharmacology Research Group, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada.
  • Bawa KK; Bernick Chair in Geriatric Psychopharmacology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.
  • Cummings JL; Departments of Psychiatry, Clinical Neurosciences, and Community Health Sciences, Hotchkiss Brain Institute, O'Brien Institute of Public Health, University of Calgary, Calgary, Alberta, Canada.
  • Husain M; Departments of Psychiatry and of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada.
  • Mortby ME; Neuropsychopharmacology Research Group, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada.
  • Robert P; Department of Brain Health, Chambers-Grundy Center for Transformative Neuroscience, School of Integrated Health Sciences, University of Nevada Las Vegas (UNLV), Las Vegas, Nevada, USA.
Int J Geriatr Psychiatry ; 38(2): e5882, 2023 02.
Article em En | MEDLINE | ID: mdl-36739588
OBJECTIVES: This narrative review describes the clinical features of apathy and depression in individuals with neurocognitive disorders (NCDs), with the goal of differentiating the two syndromes on the basis of clinical presentation, diagnostic criteria, neuropathological features, and contrasting responses to treatments. METHODS: Literature was identified using PubMed, with search terms to capture medical conditions of interest; additional references were also included based on our collective experience and knowledge of the literature. RESULTS: Evidence from current literature supports the distinction between the two disorders; apathy and depression occur with varying prevalence in individuals with NCDs, pose different risks of progression to dementia, and have distinct, if overlapping, neurobiological underpinnings. Although apathy is a distinct neuropsychiatric syndrome, distinguishing apathy from depression can be challenging, as both conditions may occur concurrently and share several overlapping features. Apathy is associated with unfavorable outcomes, especially those with neurodegenerative etiologies (e.g., Alzheimer's disease) and is associated with an increased burden for both patients and caregivers. Diagnosing apathy is important not only to serve as the basis for appropriate treatment, but also for the development of novel targeted interventions for this condition. Although there are currently no approved pharmacologic treatments for apathy, the research described in this review supports apathy as a distinct neuropsychiatric condition that warrants specific treatments aimed at alleviating patient disability. CONCLUSIONS: Despite differences between these disorders, both apathy and depression pose significant challenges to patients, their families, and caregivers; better diagnostics are needed to develop more tailored treatment and support.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Apatia / Doença de Alzheimer Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Apatia / Doença de Alzheimer Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article