Neurosurgical Approaches for Treatment-Resistant Obsessive-Compulsive Disorder.
Psychiatr Clin North Am
; 46(1): 121-132, 2023 03.
Article
em En
| MEDLINE
| ID: mdl-36740348
ABSTRACT
Treatment-resistant obsessive-compulsive disorder (trOCD) is a severely disabling, life-threatening psychiatric disorder affecting â¼0.5% of the US population. Following the failure of multiple medical and psychotherapeutic treatment lines, patients with trOCD, like others with functional disorders, may benefit from invasive neuromodulation. Cumulative evidence suggests that disrupting abnormal hyperdirect cortico-striato-thalamo-cortical (CSTC) pathway activity offers sustainable, robust symptomatic relief in most patients. Multiple surgical approaches allow for modulation of the CSTC pathway, including stereotactic lesions and electrical stimulation. This review aims to describe the modern neurosurgical approaches for trOCD, recent advances in our understanding of pathophysiology, and future therapeutic directions.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Estimulação Encefálica Profunda
/
Transtorno Obsessivo-Compulsivo
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article