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Small-molecule-mediated OGG1 inhibition attenuates pulmonary inflammation and lung fibrosis in a murine lung fibrosis model.
Tanner, L; Single, A B; Bhongir, R K V; Heusel, M; Mohanty, T; Karlsson, C A Q; Pan, L; Clausson, C-M; Bergwik, J; Wang, K; Andersson, C K; Oommen, R M; Erjefält, J S; Malmström, J; Wallner, O; Boldogh, I; Helleday, T; Kalderén, C; Egesten, A.
Afiliação
  • Tanner L; Respiratory Medicine, Allergology, & Palliative Medicine, Department of Clinical Sciences Lund, Lund University and Skåne University Hospital, SE-221 84, Lund, Sweden. lloyd.tanner@med.lu.se.
  • Single AB; Respiratory Medicine, Allergology, & Palliative Medicine, Department of Clinical Sciences Lund, Lund University and Skåne University Hospital, SE-221 84, Lund, Sweden.
  • Bhongir RKV; Respiratory Medicine, Allergology, & Palliative Medicine, Department of Clinical Sciences Lund, Lund University and Skåne University Hospital, SE-221 84, Lund, Sweden.
  • Heusel M; Division of Infection Medicine, Department of Clinical Sciences, Lund University, SE-221 84, Lund, Sweden.
  • Mohanty T; Division of Infection Medicine, Department of Clinical Sciences, Lund University, SE-221 84, Lund, Sweden.
  • Karlsson CAQ; Division of Infection Medicine, Department of Clinical Sciences, Lund University, SE-221 84, Lund, Sweden.
  • Pan L; Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, TX, 77555, USA.
  • Clausson CM; Division of Airway Inflammation, Department of Experimental Medical Sciences, Lund University, SE-221 84, Lund, Sweden.
  • Bergwik J; Respiratory Medicine, Allergology, & Palliative Medicine, Department of Clinical Sciences Lund, Lund University and Skåne University Hospital, SE-221 84, Lund, Sweden.
  • Wang K; Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, TX, 77555, USA.
  • Andersson CK; Respiratory Cell Biology, Department of Experimental Medical Sciences Lund, Lund University, SE-221 84, Lund, Sweden.
  • Oommen RM; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, SE-171 76, Stockholm, Sweden.
  • Erjefält JS; Division of Airway Inflammation, Department of Experimental Medical Sciences, Lund University, SE-221 84, Lund, Sweden.
  • Malmström J; Division of Infection Medicine, Department of Clinical Sciences, Lund University, SE-221 84, Lund, Sweden.
  • Wallner O; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, SE-171 76, Stockholm, Sweden.
  • Boldogh I; Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, TX, 77555, USA.
  • Helleday T; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, SE-171 76, Stockholm, Sweden.
  • Kalderén C; Oxcia AB, Norrbackagatan 70C, SE-113 34, Stockholm, Sweden.
  • Egesten A; Weston Park Cancer Centre, Department of Oncology and Metabolism, University of Sheffield, Sheffield, S10 2RX, UK.
Nat Commun ; 14(1): 643, 2023 02 06.
Article em En | MEDLINE | ID: mdl-36746968
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pneumonia / DNA Glicosilases / Fibrose Pulmonar Idiopática Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pneumonia / DNA Glicosilases / Fibrose Pulmonar Idiopática Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2023 Tipo de documento: Article