Increased Small Ubiquitin-like Modifier-Activating Enzyme SAE1 Promotes Hepatocellular Carcinoma by Enhancing mTOR SUMOylation.

Chen, Yuwei; Peng, Wei; Tao, Qing; Li, Shengfu; Wu, Zhenru; Zhou, Yongjie; Xu, Qing; Shu, Yuke; Xu, Yahong; Shao, Mingyang; Chen, Menglin; Shi, Yujun

Increased Small Ubiquitin-like Modifier-Activating Enzyme SAE1 Promotes Hepatocellular Carcinoma by Enhancing mTOR SUMOylation.

Chen, Yuwei; Peng, Wei; Tao, Qing; Li, Shengfu; Wu, Zhenru; Zhou, Yongjie; Xu, Qing; Shu, Yuke; Xu, Yahong; Shao, Mingyang; Chen, Menglin; Shi, Yujun.

Afiliação

Chen Y; Laboratory of Pathology, Key Laboratory of Transplant Engineering and Immunology, NHC, West China Hospital, Sichuan University, Chengdu, China.
Peng W; Department of Liver Surgery, West China Hospital, Sichuan University, Chengdu, China.
Tao Q; Laboratory of Pathology, Key Laboratory of Transplant Engineering and Immunology, NHC, West China Hospital, Sichuan University, Chengdu, China.
Li S; Laboratory of Pathology, Key Laboratory of Transplant Engineering and Immunology, NHC, West China Hospital, Sichuan University, Chengdu, China.
Wu Z; Laboratory of Pathology, Key Laboratory of Transplant Engineering and Immunology, NHC, West China Hospital, Sichuan University, Chengdu, China.
Zhou Y; Laboratory of Pathology, Key Laboratory of Transplant Engineering and Immunology, NHC, West China Hospital, Sichuan University, Chengdu, China; Laboratory of Liver Transplantation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, China
Xu Q; Laboratory of Pathology, Key Laboratory of Transplant Engineering and Immunology, NHC, West China Hospital, Sichuan University, Chengdu, China.
Shu Y; Laboratory of Pathology, Key Laboratory of Transplant Engineering and Immunology, NHC, West China Hospital, Sichuan University, Chengdu, China.
Xu Y; Laboratory of Pathology, Key Laboratory of Transplant Engineering and Immunology, NHC, West China Hospital, Sichuan University, Chengdu, China.
Shao M; Laboratory of Pathology, Key Laboratory of Transplant Engineering and Immunology, NHC, West China Hospital, Sichuan University, Chengdu, China.
Chen M; Laboratory of Pathology, Key Laboratory of Transplant Engineering and Immunology, NHC, West China Hospital, Sichuan University, Chengdu, China.
Shi Y; Laboratory of Pathology, Key Laboratory of Transplant Engineering and Immunology, NHC, West China Hospital, Sichuan University, Chengdu, China. Electronic address: shiyujun@scu.edu.cn.

Lab Invest ; 103(1): 100011, 2023 01.

Article em En | MEDLINE | ID: mdl-36748193

Assuntos

Carcinoma Hepatocelular; Neoplasias Hepáticas; Enzimas Ativadoras de Ubiquitina; Humanos; Carcinoma Hepatocelular/genética; Cisteína Endopeptidases/genética; Cisteína Endopeptidases/metabolismo; Neoplasias Hepáticas/genética; Chaperonas Moleculares/genética; Proteínas Inibidoras de STAT Ativados/genética; Proteínas Inibidoras de STAT Ativados/metabolismo; Sumoilação; Serina-Treonina Quinases TOR/metabolismo; Enzimas Ativadoras de Ubiquitina/genética; Enzimas Ativadoras de Ubiquitina/metabolismo; Ubiquitinas

Palavras-chave

SAE1; SUMOylation; bioinformatic analysis; hepatocellular carcinoma; mTOR

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carcinoma Hepatocelular / Enzimas Ativadoras de Ubiquitina / Neoplasias Hepáticas Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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