Sensitization of colonic nociceptors by IL-13 is dependent on JAK and p38 MAPK activity.

Barker, Katie H; Higham, James P; Pattison, Luke A; Chessell, Iain P; Welsh, Fraser; Smith, Ewan St J; Bulmer, David C

Barker, Katie H; Higham, James P; Pattison, Luke A; Chessell, Iain P; Welsh, Fraser; Smith, Ewan St J; Bulmer, David C.

Afiliação

Barker KH; Department of Pharmacology, University of Cambridge, Cambridge, United Kingdom.
Higham JP; Department of Pharmacology, University of Cambridge, Cambridge, United Kingdom.
Pattison LA; Department of Pharmacology, University of Cambridge, Cambridge, United Kingdom.
Chessell IP; Department of Neuroscience, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom.
Welsh F; Department of Neuroscience, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom.
Smith ESJ; Department of Pharmacology, University of Cambridge, Cambridge, United Kingdom.
Bulmer DC; Department of Pharmacology, University of Cambridge, Cambridge, United Kingdom.

Am J Physiol Gastrointest Liver Physiol ; 324(4): G250-G261, 2023 04 01.

Article em En | MEDLINE | ID: mdl-36749569

Assuntos

Doenças Inflamatórias Intestinais; Dor Visceral; Humanos; Interleucina-13/farmacologia; Nociceptores; Proteínas Quinases p38 Ativadas por Mitógeno; Capsaicina/farmacologia; Colo/inervação

Palavras-chave

IL-13; JAK; inflammatory bowel disease; nociception; p38 MAPK

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças Inflamatórias Intestinais / Dor Visceral Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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