A Ubiquitous Chromatin Opening Element and DNA Demethylation Facilitate Doxycycline-Controlled Expression during Differentiation and in Transgenic Mice.

Gödecke, Natascha; Herrmann, Sabrina; Weichelt, Viola; Wirth, Dagmar

Gödecke, Natascha; Herrmann, Sabrina; Weichelt, Viola; Wirth, Dagmar.

Afiliação

Gödecke N; RG Model Systems for Infection and Immunity, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany.
Herrmann S; RG Model Systems for Infection and Immunity, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany.
Weichelt V; RG Model Systems for Infection and Immunity, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany.
Wirth D; RG Model Systems for Infection and Immunity, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany.

ACS Synth Biol ; 12(2): 482-491, 2023 02 17.

Article em En | MEDLINE | ID: mdl-36755406

Assuntos

Cromatina; Doxiciclina; Camundongos; Animais; Camundongos Transgênicos; Doxiciclina/farmacologia; Desmetilação do DNA; Transgenes/genética; Diferenciação Celular/genética

Palavras-chave

Tet-on system; UCOE; expression silencing during differentiation; inducible gene expression; transgenic mice

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cromatina / Doxiciclina Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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PubMed Links

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cromatina / Doxiciclina Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article