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Preparation, characterization, and evaluation of antibacterial and cytotoxic activity of chitosan-polyethylene glycol nanoparticles loaded with amoxicillin as a novel drug delivery system.
Güncüm, Enes; Isiklan, Nuran; Anlas, Ceren; Bulut, Elif; Bakirel, Tülay.
Afiliação
  • Güncüm E; Faculty of Veterinary Medicine, Department of Pharmacology and Toxicology, Kirikkale University, Yahsihan, Kirikkale, Turkey.
  • Isiklan N; Faculty of Science and Arts, Department of Chemistry, Kirikkale University, Yahsihan, Kirikkale, Turkey.
  • Anlas C; Faculty of Veterinary Medicine, Department of Pharmacology and Toxicology, Istanbul University- Cerrahpasa, Buyukcekmece, Istanbul, Turkey.
  • Bulut E; Department of Zoonotic and Vector-borne Diseases, Republic of Turkey Ministry of Health, Ankara, Turkey.
  • Bakirel T; Faculty of Veterinary Medicine, Department of Pharmacology and Toxicology, Istanbul University- Cerrahpasa, Buyukcekmece, Istanbul, Turkey.
J Biomater Sci Polym Ed ; 34(12): 1660-1682, 2023 08.
Article em En | MEDLINE | ID: mdl-36756763
Amoxicillin has been encapsulated in PEG-CHI nanoparticles.The structure of nanoparticles was investigated by SEM, FTIR, and DSC studies.The nanoparticles showed an initial fast release followed by a slow release.PEG-CHI nanoparticles displayed equivalent antibacterial activity to amoxicillin, and a non-cytotoxic profile in healthy cells.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Quitosana / Nanopartículas / Antineoplásicos Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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XML
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Quitosana / Nanopartículas / Antineoplásicos Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article