Loss of aquaporin-4 results in glymphatic system dysfunction via brain-wide interstitial fluid stagnation.

Gomolka, Ryszard Stefan; Hablitz, Lauren M; Mestre, Humberto; Giannetto, Michael; Du, Ting; Hauglund, Natalie Linea; Xie, Lulu; Peng, Weiguo; Martinez, Paula Melero; Nedergaard, Maiken; Mori, Yuki

Gomolka, Ryszard Stefan; Hablitz, Lauren M; Mestre, Humberto; Giannetto, Michael; Du, Ting; Hauglund, Natalie Linea; Xie, Lulu; Peng, Weiguo; Martinez, Paula Melero; Nedergaard, Maiken; Mori, Yuki.

Afiliação

Gomolka RS; Center for Translational Neuromedicine, University of Copenhagen, Copenhagen, Denmark.
Hablitz LM; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, United States.
Mestre H; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, United States.
Giannetto M; Department of Neurology, University of Pennsylvania, Philadelphia, United States.
Du T; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, United States.
Hauglund NL; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, United States.
Xie L; School of Pharmacy, China Medical University, Shenyang, China.
Peng W; Center for Translational Neuromedicine, University of Copenhagen, Copenhagen, Denmark.
Martinez PM; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, United States.
Nedergaard M; Center for Translational Neuromedicine, University of Copenhagen, Copenhagen, Denmark.
Mori Y; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, United States.

Elife ; 122023 02 09.

Article em En | MEDLINE | ID: mdl-36757363

Assuntos

Sistema Glinfático; Camundongos; Humanos; Animais; Sistema Glinfático/diagnóstico por imagem; Sistema Glinfático/metabolismo; Líquido Extracelular/metabolismo; Encéfalo/diagnóstico por imagem; Encéfalo/metabolismo; Aquaporina 4/genética; Aquaporina 4/metabolismo; Água/metabolismo

Palavras-chave

CSF space; aquaporin-4 channel; diffusion weighted-imaging; glymphatic system; intravoxel-incoherent motion dwi; mouse; neuroscience

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sistema Glinfático Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sistema Glinfático Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article