Single-molecule footprinting identifies context-dependent regulation of enhancers by DNA methylation.

Kreibich, Elisa; Kleinendorst, Rozemarijn; Barzaghi, Guido; Kaspar, Sarah; Krebs, Arnaud R

Kreibich, Elisa; Kleinendorst, Rozemarijn; Barzaghi, Guido; Kaspar, Sarah; Krebs, Arnaud R.

Afiliação

Kreibich E; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Meyerhofstraße 1, 69117 Heidelberg, Germany; Faculty of Biosciences, Collaboration for Joint PhD Degree between EMBL and Heidelberg University, Heidelberg, Germany.
Kleinendorst R; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Meyerhofstraße 1, 69117 Heidelberg, Germany.
Barzaghi G; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Meyerhofstraße 1, 69117 Heidelberg, Germany; Faculty of Biosciences, Collaboration for Joint PhD Degree between EMBL and Heidelberg University, Heidelberg, Germany.
Kaspar S; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Meyerhofstraße 1, 69117 Heidelberg, Germany.
Krebs AR; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Meyerhofstraße 1, 69117 Heidelberg, Germany. Electronic address: arnaud.krebs@embl.de.

Mol Cell ; 83(5): 787-802.e9, 2023 03 02.

Article em En | MEDLINE | ID: mdl-36758546

Assuntos

Metilação de DNA; Elementos Facilitadores Genéticos; Animais; Cromatina; Fatores de Transcrição/metabolismo; Regulação da Expressão Gênica; Mamíferos/metabolismo

Palavras-chave

DNA methylation; enhancers; epigenetics; gene regulation; genomics; single-molecule footprinting; transcription factors

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Elementos Facilitadores Genéticos / Metilação de DNA Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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