Mycobacterial phosphodiesterase Rv0805 is a virulence determinant and its cyclic nucleotide hydrolytic activity is required for propionate detoxification.

McDowell, James R; Bai, Guangchun; Lasek-Nesselquist, Erica; Eisele, Leslie E; Wu, Yan; Hurteau, Gregory; Johnson, Richard; Bai, Yinlan; Chen, Yong; Chan, John; McDonough, Kathleen A

McDowell, James R; Bai, Guangchun; Lasek-Nesselquist, Erica; Eisele, Leslie E; Wu, Yan; Hurteau, Gregory; Johnson, Richard; Bai, Yinlan; Chen, Yong; Chan, John; McDonough, Kathleen A.

Afiliação

McDowell JR; Wadsworth Center, New York State Department of Health, Albany, New York, USA.
Bai G; Department of Biomedical Sciences, School of Public Health, University at Albany, SUNY, Albany, New York, USA.
Lasek-Nesselquist E; Wadsworth Center, New York State Department of Health, Albany, New York, USA.
Eisele LE; Department of Immunology and Microbial Disease, MC-151, Albany Medical College, Albany, New York, USA.
Wu Y; Wadsworth Center, New York State Department of Health, Albany, New York, USA.
Hurteau G; Department of Biomedical Sciences, School of Public Health, University at Albany, SUNY, Albany, New York, USA.
Johnson R; Wadsworth Center, New York State Department of Health, Albany, New York, USA.
Bai Y; Wadsworth Center, New York State Department of Health, Albany, New York, USA.
Chen Y; Wadsworth Center, New York State Department of Health, Albany, New York, USA.
Chan J; Wadsworth Center, New York State Department of Health, Albany, New York, USA.
McDonough KA; Department of Biomedical Sciences, School of Public Health, University at Albany, SUNY, Albany, New York, USA.

Mol Microbiol ; 119(4): 401-422, 2023 04.

Article em En | MEDLINE | ID: mdl-36760076

Assuntos

Mycobacterium tuberculosis; Diester Fosfórico Hidrolases; Animais; Camundongos; Diester Fosfórico Hidrolases/genética; Diester Fosfórico Hidrolases/metabolismo; Nucleotídeos Cíclicos/metabolismo; Propionatos/metabolismo; Virulência; Hidrólise; Vacina BCG/metabolismo; Glicerol/metabolismo; AMP Cíclico/metabolismo; Mycobacterium tuberculosis/genética; Mycobacterium tuberculosis/metabolismo; 3',5'-AMP Cíclico Fosfodiesterases/genética; 3',5'-AMP Cíclico Fosfodiesterases/metabolismo

Palavras-chave

TB complex bacteria; cAMP signaling; carbon metabolism; cyclic nucleotide phosphodiesterase

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Diester Fosfórico Hidrolases / Mycobacterium tuberculosis Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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