Ribociclib-induced hepatotoxicity.
J Oncol Pharm Pract
; 29(5): 1275-1277, 2023 Jul.
Article
em En
| MEDLINE
| ID: mdl-36762416
ABSTRACT
INTRODUCTION:
Cyclin-dependent kinase (CDK) 4/6 inhibitors have shown a different adverse effect. In this case, persistent grade 3 hepatoxicity was observed after ribociclib. Therefore, ribociclib therapy was stopped, and then palbociclib was introduced. Transaminase levels returned to normal by switching to palbociclib therapy. CASE REPORT 71-year-old postmenopausal female patient with luminal subtypes of metastatic breast cancer treated with ribociclib. MANAGEMENT &OUTCOME:
Grade 3 hepatotoxicity secondary to ribociclib developed. She was successfully treated with palbociclib 125â mg.DISCUSSION:
In our case, palbociclib was started with a full dose, to increase treatment success. Starting with a 125â mg dose was not cause any toxicity. Nevertheless, laboratory follow-up is required in terms of neutropenia and increased transaminases.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
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Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos
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Doença Hepática Induzida por Substâncias e Drogas
Tipo de estudo:
Etiology_studies
Limite:
Aged
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Female
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Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article