The mTORC2/AKT/VCP axis is associated with quality control of the stalled translation of poly(GR) dipeptide repeats in C9-ALS/FTD.

Li, Yu; Geng, Ji; Rimal, Suman; Wang, Haochuan; Liu, Xiangguo; Lu, Bingwei; Li, Shuangxi

Li, Yu; Geng, Ji; Rimal, Suman; Wang, Haochuan; Liu, Xiangguo; Lu, Bingwei; Li, Shuangxi.

Afiliação

Li Y; Shandong Provincial Key Laboratory of Animal Cell and Developmental Biology, School of Life Sciences, Shandong University, Qingdao, China.
Geng J; Shandong Provincial Key Laboratory of Animal Cell and Developmental Biology, School of Life Sciences, Shandong University, Qingdao, China; Department of Pathology, Stanford University School of Medicine, Stanford, California, USA.
Rimal S; Department of Pathology, Stanford University School of Medicine, Stanford, California, USA.
Wang H; Shandong Provincial Key Laboratory of Animal Cell and Developmental Biology, School of Life Sciences, Shandong University, Qingdao, China.
Liu X; Shandong Provincial Key Laboratory of Animal Cell and Developmental Biology, School of Life Sciences, Shandong University, Qingdao, China.
Lu B; Department of Pathology, Stanford University School of Medicine, Stanford, California, USA. Electronic address: bingwei@stanford.edu.
Li S; Shandong Provincial Key Laboratory of Animal Cell and Developmental Biology, School of Life Sciences, Shandong University, Qingdao, China. Electronic address: shuangxi@sdu.edu.cn.

J Biol Chem ; 299(3): 102995, 2023 03.

Article em En | MEDLINE | ID: mdl-36764521

Assuntos

Esclerose Lateral Amiotrófica; Demência Frontotemporal; Animais; Esclerose Lateral Amiotrófica/metabolismo; Proteína C9orf72/genética; Proteína C9orf72/metabolismo; Dipeptídeos/metabolismo; Expansão das Repetições de DNA; Proteínas de Ligação a DNA/metabolismo; Drosophila/metabolismo; Demência Frontotemporal/patologia; Mamíferos/metabolismo; Proteínas Proto-Oncogênicas c-akt/genética; Proteínas Proto-Oncogênicas c-akt/metabolismo; Controle de Qualidade; Proteína com Valosina/metabolismo; Alvo Mecanístico do Complexo 2 de Rapamicina/metabolismo

Palavras-chave

APP; C9-ALS/FTD; FUS; TDP-43; mTORC2/AKT/VCP axis; poly(GR)

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Demência Frontotemporal / Esclerose Lateral Amiotrófica Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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