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Autoimmune and Metabolic Diseases and the Risk of Early-Onset Colorectal Cancer, a Nationwide Nested Case-Control Study.
Lundqvist, Erik; Myrberg, Ida Hed; Boman, Sol Erika; Saraste, Deborah; Weibull, Caroline E; Landerholm, Kalle; Haapaniemi, Staffan; Martling, Anna; Myrelid, Pär; Nordenvall, Caroline.
Afiliação
  • Lundqvist E; Department of Biomedical and Clinical Sciences, Linköping University, 58183 Linköping, Sweden.
  • Myrberg IH; Department of Surgery, Vrinnevi Hospital, 60379 Norrköping, Sweden.
  • Boman SE; Department of Medicine, Division of Clinical Epidemiology, Karolinska University Hospital, Karolinska Institutet, 17177 Stockholm, Sweden.
  • Saraste D; Department of Medicine, Division of Clinical Epidemiology, Karolinska University Hospital, Karolinska Institutet, 17177 Stockholm, Sweden.
  • Weibull CE; Department of Surgery, Södersjukhuset, 11883 Stockholm, Sweden.
  • Landerholm K; Department of Molecular Medicine and Surgery, Karolinska Institutet, Division of Coloproctology, Center for Digestive Diseases, Karolinska University Hospital, 17177 Stockholm, Sweden.
  • Haapaniemi S; Department of Medicine, Division of Clinical Epidemiology, Karolinska University Hospital, Karolinska Institutet, 17177 Stockholm, Sweden.
  • Martling A; Department of Biomedical and Clinical Sciences, Linköping University, 58183 Linköping, Sweden.
  • Myrelid P; Department of Surgery, Ryhov County Hospital, 55305 Jönköping, Sweden.
  • Nordenvall C; Department of Biomedical and Clinical Sciences, Linköping University, 58183 Linköping, Sweden.
Cancers (Basel) ; 15(3)2023 Jan 22.
Article em En | MEDLINE | ID: mdl-36765646
ABSTRACT
Incidence of early-onset (<50 years) colorectal cancer (EOCRC) is increasing in developed countries. The aim was to investigate autoimmune and metabolic conditions as risk factors for EOCRC. In a nationwide nested case-control study, we included all EOCRC cases in Sweden diagnosed during 2007-2016, together with controls, matched for birth year, sex, and county. Information on exposure of autoimmune or metabolic disease was collected from the National Patient Register and Prescribed Drugs Registry. Hazard ratios (HR) as measures of the association between EOCRC and the exposures were estimated using conditional logistic regression. In total, 2626 EOCRC patients and 15,756 controls were included. A history of metabolic disease nearly doubled the incidence hazard of EOCRC (HR 1.82, 95% CI 1.66-1.99). A sixfold increased incidence hazard of EOCRC (HR 5.98, 95% CI 4.78-7.48) was seen in those with inflammatory bowel disease (IBD), but the risk increment decreased in presence of concomitant metabolic disease (HR 3.65, 95% CI 2.57-5.19). Non-IBD autoimmune disease was not statistically significantly associated with EOCRC. IBD and metabolic disease are risk factors for EOCRC and should be considered in screening guidelines.
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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Etiology_studies / Guideline / Observational_studies / Risk_factors_studies Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Etiology_studies / Guideline / Observational_studies / Risk_factors_studies Idioma: En Ano de publicação: 2023 Tipo de documento: Article