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Framework for Adoption of Next-Generation Sequencing (NGS) Globally in the Oncology Area.
Horgan, Denis; Hamdi, Yosr; Lal, Jonathan A; Nyawira, Teresia; Meyer, Salomé; Kondji, Dominique; Francisco, Ngiambudulu M; De Guzman, Roselle; Paul, Anupriya; Bernard, Branka; Reddy Nallamalla, Krishna; Park, Woong-Yang; Triapthi, Vijay; Tripathi, Ravikant; Johns, Amber; Singh, Mohan P; Phipps, Maude E; Dube, France; Rasheed, Hadi Mohamad Abu; Kozaric, Marta; Pinto, Joseph A; Doral Stefani, Stephen; Aponte Rueda, Maria Eugenia; Fujita Alarcon, Ricardo; Barrera-Saldana, Hugo A.
Afiliação
  • Horgan D; European Alliance for Personalised Medicine, 1040 Brussels, Belgium.
  • Hamdi Y; Department of Molecular and Cellular Engineering, Jacob Institute of Biotechnology and Bioengineering, Sam Higginbottom University of Agriculture, Technology and Sciences, Prayagraj 211007, India.
  • Lal JA; Laboratory of Biomedical Genomics and Oncogenetics, Institut Pasteur de Tunis, University of Tunis El Manar, Tunis 1002, Tunisia.
  • Nyawira T; Laboratory of Human and Experimental Pathology, Institut Pasteur de Tunis, Tunis 1002, Tunisia.
  • Meyer S; Department of Molecular and Cellular Engineering, Jacob Institute of Biotechnology and Bioengineering, Sam Higginbottom University of Agriculture, Technology and Sciences, Prayagraj 211007, India.
  • Kondji D; Department of Genetics and Cell Biology, GROW School of Oncology and Developmental Biology, Faculty of Health, Medicine and Life Sciences, Institute for Public Health Genomics, Maastricht University, 6211 LK Maastricht, The Netherlands.
  • Francisco NM; National Commission for Science, Technology and Innovation in Kenya (NACOSTI), Nairobi 00100, Kenya.
  • De Guzman R; Cancer Alliance, Cape Town 7700, South Africa.
  • Paul A; Health & Development Communication, Building Capacity for Better Health in Africa, Yaounde P.O. Box 2032, Cameroon.
  • Bernard B; Grupo de Investigação Microbiana e Imunológica, Instituto Nacional de Investigação em Saúde (National Institute for Health Research), Luanda 3635, Angola.
  • Reddy Nallamalla K; Oncology and Pain Management Section, Manila Central University-Filemon D. Tanchoco Medical Foundation Hospital, Caloocan 1400, Philippines.
  • Park WY; Department of Mathematics and Statistics, Faculty of Science, Sam Higginbottom University of Agriculture, Technology and Sciences, Prayagraj 211007, India.
  • Triapthi V; European Alliance for Personalised Medicine, 1040 Brussels, Belgium.
  • Tripathi R; Mediterranean Institute for Life Sciences, 21000 Split, Croatia.
  • Johns A; ACCESS Health India, Hyderabad 500086, India.
  • Singh MP; Samsung Medical Center, Samsung Genome Institute, Sungkyunkwan University, Seoul 06351, Republic of Korea.
  • Phipps ME; Department of Molecular and Cellular Engineering, Jacob Institute of Biotechnology and Bioengineering, Sam Higginbottom University of Agriculture, Technology and Sciences, Prayagraj 211007, India.
  • Dube F; Department Health Government of India, Ministry of Labor, New Delhi 110001, India.
  • Rasheed HMA; Cancer Division, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Sydney 2010, Australia.
  • Kozaric M; Center of Biotechnology, University of Allahabad, Allahabad 211002, India.
  • Pinto JA; Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Subang Jaya 47500, Selangor, Malaysia.
  • Doral Stefani S; Precision Medicine and Breast Cancer Department, Astra Zeneca, 1800 Concord Pike, Wilmington, DE 19803, USA.
  • Aponte Rueda ME; Qatar Cancer Society, Doha 22944, Qatar.
  • Fujita Alarcon R; European Alliance for Personalised Medicine, 1040 Brussels, Belgium.
  • Barrera-Saldana HA; Center for Basic and Translational Research, Auna Ideas, Lima 15036, Peru.
Healthcare (Basel) ; 11(3)2023 Feb 02.
Article em En | MEDLINE | ID: mdl-36767006
Radical new possibilities of improved treatment of cancer are on offer from an advanced medical technology already demonstrating its significance: next-generation sequencing (NGS). This refined testing provides unprecedentedly precise diagnoses and permits the use of focused and highly personalized treatments. However, across regions globally, many cancer patients will continue to be denied the benefits of NGS as long as some of the yawning gaps in its implementation remain unattended. The challenges at the regional and national levels are linked because putting the solutions into effect is highly dependent on cooperation between regional- and national-level cooperation, which could be hindered by shortfalls in interpretation or understanding. The aim of the paper was to define and explore the necessary conditions for NGS and make recommendations for effective implementation based on extensive exchanges with policy makers and stakeholders. As a result, the European Alliance for Personalised Medicine (EAPM) developed a maturity framework structured around demand-side and supply-side issues to enable interested stakeholders in different countries to self-evaluate according to a common matrix. A questionnaire was designed to identify the current status of NGS implementation, and it was submitted to different experts in different institutions globally. This revealed significant variability in the different aspects of NGS uptake. Within different regions globally, to ensure those conditions are right, this can be improved by linking efforts made at the national level, where patients have needs and where care is delivered, and at the global level, where major policy initiatives in the health field are underway or in preparation, many of which offer direct or indirect pathways for building those conditions. In addition, in a period when consensus is still incomplete and catching up is needed at a political level to ensure rational allocation of resources-even within individual countries-to enable the best ways to make the necessary provisions for NGS, a key recommendation is to examine where closer links between national and regional actions could complement, support, and mutually reinforce efforts to improve the situation for patients.
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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Guideline / Qualitative_research Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Guideline / Qualitative_research Idioma: En Ano de publicação: 2023 Tipo de documento: Article