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Effects of Transcranial Pulse Stimulation (TPS) on Adults with Symptoms of Depression-A Pilot Randomized Controlled Trial.
Cheung, Teris; Li, Tim Man Ho; Ho, Yuen Shan; Kranz, Georg; Fong, Kenneth N K; Leung, Sau Fong; Lam, Simon Ching; Yeung, Wing Fai; Lam, Joyce Yuen Ting; Fong, Kwan Hin; Beisteiner, Roland; Xiang, Yu-Tao; Cheng, Calvin Pak Wing.
Afiliação
  • Cheung T; School of Nursing, The Hong Kong Polytechnic University, Hong Kong SAR, China.
  • Li TMH; Department of Psychiatry, The Chinese University of Hong Kong, Hong Kong SAR, China.
  • Ho YS; School of Nursing, The Hong Kong Polytechnic University, Hong Kong SAR, China.
  • Kranz G; Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong SAR, China.
  • Fong KNK; Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong SAR, China.
  • Leung SF; School of Nursing, The Hong Kong Polytechnic University, Hong Kong SAR, China.
  • Lam SC; School of Nursing, Tung Wah College, Hong Kong SAR, China.
  • Yeung WF; School of Nursing, The Hong Kong Polytechnic University, Hong Kong SAR, China.
  • Lam JYT; School of Nursing, The Hong Kong Polytechnic University, Hong Kong SAR, China.
  • Fong KH; School of Nursing, The Hong Kong Polytechnic University, Hong Kong SAR, China.
  • Beisteiner R; Department of Neurology, Medical University of Vienna, 1090 Vienna, Austria.
  • Xiang YT; Unit of Psychiatry, Department of Public Health and Medicinal Administration, Institute of Translational Medicine, University of Macau, Macao SAR, China.
  • Cheng CPW; Department of Psychiatry, University of Hong Kong, Hong Kong SAR, China.
Article em En | MEDLINE | ID: mdl-36767702
ABSTRACT
Transcranial pulse stimulation (TPS) is a recent development in non-invasive brain stimulations (NIBS) that has been proven to be effective in terms of significantly improving Alzheimer patients' cognition, memory, and execution functions. Nonetheless, there is, currently, no trial evaluating the efficacy of TPS on adults with major depression disorder (MDD) nationwide. In this single-blinded, randomized controlled trial, a 2-week TPS treatment comprising six 30 min TPS sessions were administered to participants. Participants were randomized into either the TPS group or the Waitlist Control (WC) group, stratified by gender and age according to a 11 ratio. Our primary outcome was evaluated by the Hamilton depression rating scale-17 (HDRS-17). We recruited 30 participants that were aged between 18 and 54 years, predominantly female (73%), and ethnic Chinese from 1 August to 31 October 2021. Moreover, there was a significant group x time interaction (F(1, 28) = 18.8, p < 0.001). Further, when compared with the WC group, there was a significant reduction in the depressive symptom severity in the TPS group (mean difference = -6.60, p = 0.02, and Cohen's d = -0.93). The results showed a significant intervention effect; in addition, the effect was large and sustainable at the 3-month follow-up. In this trial, it was found that TPS is effective in reducing depressive symptoms among adults with MDD.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtorno Depressivo Maior / Estimulação Transcraniana por Corrente Contínua Tipo de estudo: Clinical_trials / Diagnostic_studies Limite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtorno Depressivo Maior / Estimulação Transcraniana por Corrente Contínua Tipo de estudo: Clinical_trials / Diagnostic_studies Limite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2023 Tipo de documento: Article