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Gene Expression Profile of Uterine Leiomyoma from Women Exposed to Different Air Pollution Levels in Metropolitan Cities of Sao Paulo, Brazil.
Dos Anjos, Laura Gonzalez; de Almeida, Bruna Cristine; Baracat, Edmund Chada; Al-Hendy, Ayman; Yang, Qiwei; Carvalho, Katia Candido.
Afiliação
  • Dos Anjos LG; Laboratório de Ginecologia Estrutural e Molecular (LIM 58), Disciplina de Ginecologia, Departamento de Obstetricia e Ginecologia, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo (HCFMUSP), São Paulo 05403-010, Brazil.
  • de Almeida BC; Laboratório de Ginecologia Estrutural e Molecular (LIM 58), Disciplina de Ginecologia, Departamento de Obstetricia e Ginecologia, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo (HCFMUSP), São Paulo 05403-010, Brazil.
  • Baracat EC; Laboratório de Ginecologia Estrutural e Molecular (LIM 58), Disciplina de Ginecologia, Departamento de Obstetricia e Ginecologia, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo (HCFMUSP), São Paulo 05403-010, Brazil.
  • Al-Hendy A; Department of Obstetrics and Gynecology, University of Chicago, Chicago, IL 60637, USA.
  • Yang Q; Department of Obstetrics and Gynecology, University of Chicago, Chicago, IL 60637, USA.
  • Carvalho KC; Laboratório de Ginecologia Estrutural e Molecular (LIM 58), Disciplina de Ginecologia, Departamento de Obstetricia e Ginecologia, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo (HCFMUSP), São Paulo 05403-010, Brazil.
Int J Mol Sci ; 24(3)2023 Jan 26.
Article em En | MEDLINE | ID: mdl-36768749
Leiomyomas (LMs) are the most frequent uterine benign tumors, representing the leading cause of hysterectomy indications worldwide. They are highly associated with women's reproductive complications, and endocrine disruptors may influence their etiology. In this sense, air pollution represents a relevant hormonal disruptor that acts on key signaling pathways, resulting in tumor development and infertility. Our goal was to evaluate submucosal LM samples from patients living in the metropolitan and Sao Paulo city regions, focusing on genes involved in tumor development and infertility features. Twenty-four patients were selected based on their region of residence and clinical information availability. Several genes were differentially expressed between women living in metropolitan areas and Sao Paulo city. Significant associations were observed between BCL-2, DVL1, FGFR3, and WNT5b downregulation and contraceptive use in the samples from women living in Sao Paulo city. ESR1 and HHAT downregulation was associated with ethnicity. WNT5b and GREM were associated with LM treatment and related pathologies, respectively. In the samples from women living in other cities of the metropolitan region, abortion occurrence was associated with BMP4 upregulation. Although further studies may be necessary, our results showed that air pollution exposure influences the expression of genes related to LM development and female reproductive features.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Poluentes Atmosféricos / Poluição do Ar / Infertilidade / Leiomioma Tipo de estudo: Etiology_studies Limite: Female / Humans / Pregnancy País como assunto: America do sul / Brasil Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Poluentes Atmosféricos / Poluição do Ar / Infertilidade / Leiomioma Tipo de estudo: Etiology_studies Limite: Female / Humans / Pregnancy País como assunto: America do sul / Brasil Idioma: En Ano de publicação: 2023 Tipo de documento: Article