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Stressor-Specific Sex Differences in Amygdala-Frontal Cortex Networks.
Bürger, Zoé; Müller, Veronika I; Hoffstaedter, Felix; Habel, Ute; Gur, Ruben C; Windischberger, Christian; Moser, Ewald; Derntl, Birgit; Kogler, Lydia.
Afiliação
  • Bürger Z; Department of Psychiatry and Psychotherapy, Tübingen Centre for Mental Health (TüCMH), Medical Faculty, University of Tübingen, 72076 Tübingen, Germany.
  • Müller VI; Institute of Neuroscience and Medicine, INM-7, Research Centre Jülich, 52425 Jülich, Germany.
  • Hoffstaedter F; Institute of Systems Neuroscience, Medical Faculty, Heinrich Heine University, 40225 Düsseldorf, Germany.
  • Habel U; Institute of Neuroscience and Medicine, INM-7, Research Centre Jülich, 52425 Jülich, Germany.
  • Gur RC; Institute of Systems Neuroscience, Medical Faculty, Heinrich Heine University, 40225 Düsseldorf, Germany.
  • Windischberger C; Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, 52074 Aachen, Germany.
  • Moser E; JARA BRAIN Institute I, Translational Brain Medicine, 52428 Jülich, Germany.
  • Derntl B; Neuropsychiatry Division, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Kogler L; High-Field MR Center, Medical University of Vienna, 1090 Vienna, Austria.
J Clin Med ; 12(3)2023 Jan 22.
Article em En | MEDLINE | ID: mdl-36769521
Females and males differ in stress reactivity, coping, and the prevalence rates of stress-related disorders. According to a neurocognitive framework of stress coping, the functional connectivity between the amygdala and frontal regions (including the dorsolateral prefrontal cortex (dlPFC), ventral anterior cingulate cortex (vACC), and medial prefrontal cortex (mPFC)) plays a key role in how people deal with stress. In the current study, we investigated the effects of sex and stressor type in a within-subject counterbalanced design on the resting-state functional connectivity (rsFC) of the amygdala and these frontal regions in 77 healthy participants (40 females). Both stressor types led to changes in subjective ratings, with decreasing positive affect and increasing negative affect and anger. Females showed higher amygdala-vACC and amygdala-mPFC rsFC for social exclusion than for achievement stress, and compared to males. Whereas a higher amygdala-vACC rsFC indicates the activation of emotion processing and coping, a higher amygdala-mPFC rsFC indicates feelings of reward and social gain, highlighting the positive effects of social affiliation. Thus, for females, feeling socially affiliated might be more fundamental than for males. Our data indicate interactions of sex and stressor in amygdala-frontal coupling, which translationally contributes to a better understanding of the sex differences in prevalence rates and stress coping.
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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Risk_factors_studies Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Risk_factors_studies Idioma: En Ano de publicação: 2023 Tipo de documento: Article