The effect of fecapentaenes on nuclear aberrations in murine colonic epithelial cells.
Cancer Lett
; 37(2): 199-203, 1987 Oct 30.
Article
em En
| MEDLINE
| ID: mdl-3677054
ABSTRACT
Fecapentaenes, human fecal mutagens of bacterial origin, were intrarectally administered to mice in suppository form. Despite the strong, positive mutagenic response of fecanpentaenes using Ames tester strains TA 98 and TA 100, no increase in nuclear aberrations, taken as a measure of genotoxicity in colonic epithelial cells, was observed over control levels. In fecapentaene treated animals, however, the incidence of mitotic figures was increased above control levels to values comparable to those observed in mice treated with the known colon carcinogen, N-ethyl-N-nitrosourea. Thus, it would appear that fecapentaenes are not cytotoxic to murine colonic epithelia as judged by the nuclear aberration assay.
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Base de dados:
MEDLINE
Assunto principal:
Polienos
/
Núcleo Celular
/
Colo
/
Mutagênicos
Limite:
Animals
Idioma:
En
Ano de publicação:
1987
Tipo de documento:
Article