1H-Indazoles derivatives targeting PI3K/AKT/mTOR pathway: Synthesis, anti-tumor effect and molecular mechanism.

Wang, Shuai; Shi, Jian-Tao; Wang, Xing-Rong; Mu, Hong-Xia; Wang, Xue-Ting; Xu, Kai-Yan; Wang, Qing-Shan; Chen, Shi-Wu

Wang, Shuai; Shi, Jian-Tao; Wang, Xing-Rong; Mu, Hong-Xia; Wang, Xue-Ting; Xu, Kai-Yan; Wang, Qing-Shan; Chen, Shi-Wu.

Afiliação

Wang S; School of Pharmacy & Collaborative Innovation Center for Northwestern Chinese Medicine, Lanzhou University, Lanzhou 730000, China.
Shi JT; School of Pharmacy & Collaborative Innovation Center for Northwestern Chinese Medicine, Lanzhou University, Lanzhou 730000, China.
Wang XR; School of Pharmacy & Collaborative Innovation Center for Northwestern Chinese Medicine, Lanzhou University, Lanzhou 730000, China.
Mu HX; School of Pharmacy & Collaborative Innovation Center for Northwestern Chinese Medicine, Lanzhou University, Lanzhou 730000, China.
Wang XT; School of Pharmacy & Collaborative Innovation Center for Northwestern Chinese Medicine, Lanzhou University, Lanzhou 730000, China.
Xu KY; School of Pharmacy & Collaborative Innovation Center for Northwestern Chinese Medicine, Lanzhou University, Lanzhou 730000, China.
Wang QS; School of Pharmacy & Collaborative Innovation Center for Northwestern Chinese Medicine, Lanzhou University, Lanzhou 730000, China.
Chen SW; School of Pharmacy & Collaborative Innovation Center for Northwestern Chinese Medicine, Lanzhou University, Lanzhou 730000, China; State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China. Electronic address: chenshw@lzu.edu.cn.

Bioorg Chem ; 133: 106412, 2023 04.

Article em En | MEDLINE | ID: mdl-36773456

Assuntos

Indazóis; Neoplasias; Humanos; Apoptose; Linhagem Celular Tumoral; Proliferação de Células; Neoplasias/tratamento farmacológico; Fosfatidilinositol 3-Quinases/metabolismo; Inibidores de Fosfoinositídeo-3 Quinase/farmacologia; Inibidores de Proteínas Quinases/farmacologia; Proteínas Proto-Oncogênicas c-akt/metabolismo; Transdução de Sinais; Serina-Treonina Quinases TOR/metabolismo; Indazóis/química; Indazóis/farmacologia

Palavras-chave

Antitumor; Indazole; PI3K/AKT/mTOR

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Indazóis / Neoplasias Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Indazóis / Neoplasias Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article