Ultra-processed foods and mortality: analysis from the Prospective Urban and Rural Epidemiology study.
Am J Clin Nutr
; 117(1): 55-63, 2023 01.
Article
em En
| MEDLINE
| ID: mdl-36789944
ABSTRACT
BACKGROUND:
Higher intake of ultra-processed foods (UPFs) has been associated with increased risk of CVD and mortality in observational studies from Western countries but data from non-Western countries are limited.OBJECTIVES:
We aimed to assess the association between consumption of UPFs and risk of mortality and major CVD in a cohort from multiple world regions.DESIGN:
This analysis includes 138,076 participants without a history of CVD between the ages of 35 and 70 y living on 5 continents, with a median follow-up of 10.2 y. We used country-specific validated food-frequency questionnaires to determine individuals' food intake. We classified foods and beverages based on the NOVA classification into UPFs. The primary outcome was total mortality (CV and non-CV mortality) and secondary outcomes were incident major cardiovascular events. We calculated hazard ratios using multivariable Cox frailty models and evaluated the association of UPFs with total mortality, CV mortality, non-CV mortality, and major CVD events.RESULTS:
In this study, 9227 deaths and 7934 major cardiovascular events were recorded during the follow-up period. We found a diet high in UPFs (≥2 servings/d compared with 0 intake) was associated with higher risk of mortality (HR 1.28; 95% CI 1.15, 1.42; P-trend < 0.001), CV mortality (HR 1.17; 95% CI 0.98, 1.41; P-trend = 0.04), and non-CV mortality (HR 1.32; 95% CI 1.17, 1.50; P-trend < 0.001). We did not find a significant association between UPF intake and risk of major CVD.CONCLUSIONS:
A diet with a high intake of UPFs was associated with a higher risk of mortality in a diverse multinational study. Globally, limiting the consumption of UPFs should be encouraged.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doenças Cardiovasculares
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Alimento Processado
Tipo de estudo:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
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Screening_studies
Limite:
Adult
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Aged
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Humans
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Middle aged
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article