Tiagabine suppresses pentylenetetrazole-induced seizures in mice and improves behavioral and cognitive parameters by modulating BDNF/TrkB expression and neuroinflammatory markers.

Javaid, Sana; Alqahtani, Faleh; Ashraf, Waseem; Anjum, Syed Muhammad Muneeb; Rasool, Muhammad Fawad; Ahmad, Tanveer; Alasmari, Fawaz; Alasmari, Abdullah F; Alqarni, Saleh Abdullah; Imran, Imran

Javaid, Sana; Alqahtani, Faleh; Ashraf, Waseem; Anjum, Syed Muhammad Muneeb; Rasool, Muhammad Fawad; Ahmad, Tanveer; Alasmari, Fawaz; Alasmari, Abdullah F; Alqarni, Saleh Abdullah; Imran, Imran.

Afiliação

Javaid S; Department of Pharmacology, Faculty of Pharmacy, Bahauddin Zakariya University, Multan 60800, Pakistan; Department of Pharmacy, The Women University, Multan 60000, Pakistan.
Alqahtani F; Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia. Electronic address: afaleh@ksu.edu.sa.
Ashraf W; Department of Pharmacology, Faculty of Pharmacy, Bahauddin Zakariya University, Multan 60800, Pakistan.
Anjum SMM; The Institute of Pharmaceutical Sciences, University of Veterinary & Animal Sciences, Lahore 75270, Pakistan.
Rasool MF; Department of Pharmacy Practice, Faculty of Pharmacy, Bahauddin Zakariya University, Multan 60800, Pakistan.
Ahmad T; Institut pour l'Avancée des Biosciences, Centre de Recherche UGA / INSERM U1209 / CNRS 5309, Université Grenoble Alpes, France.
Alasmari F; Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Alasmari AF; Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Alqarni SA; Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Imran I; Department of Pharmacology, Faculty of Pharmacy, Bahauddin Zakariya University, Multan 60800, Pakistan. Electronic address: imran.ch@bzu.edu.pk.

Biomed Pharmacother ; 160: 114406, 2023 Apr.

Article em En | MEDLINE | ID: mdl-36791567

Assuntos

Epilepsia; Excitação Neurológica; Animais; Masculino; Camundongos; Anticonvulsivantes; Fator Neurotrófico Derivado do Encéfalo/metabolismo; Cognição; Epilepsia/induzido quimicamente; Epilepsia/tratamento farmacológico; Epilepsia/metabolismo; Pentilenotetrazol/farmacologia; RNA Mensageiro/genética; Convulsões/induzido quimicamente; Convulsões/tratamento farmacológico; Tiagabina

Palavras-chave

Anxiety; Electroencephalogram; Epilepsy; Pentylenetetrazole; Real-time PCR; Tiagabine

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Epilepsia / Excitação Neurológica Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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