Immunosuppressive Bibenzyl-phenylpropane Hybrids from Dendrobium devonianum.
Chem Biodivers
; 20(3): e202201185, 2023 Mar.
Article
em En
| MEDLINE
| ID: mdl-36795028
ABSTRACT
Two new bibenzyl-phenylpropane hybrids, dendrophenols A and B (1 and 2), along with nine known bibenzyls, were isolated from the aerial part of Dendrobium devonianum Paxt. Their structures were determined by extensive spectroscopic methods and methylation. Bioassays revealed that compounds 1-9 were specifically immunosuppressive to T lymphocytes with IC50 values ranging from 0.41 to 9.4â
µM, of which compounds 1 (IC50 =1.62â
µM) and 2 (IC50 =0.41â
µM) were promising immunosuppressive agents for T lymphocytes with the selectivity indices of 19.9 and 79.5, respectively.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Bibenzilas
/
Dendrobium
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article