Experimental study of EGFR-TKI aumolertinib combined with ionizing radiation in EGFR mutated NSCLC brain metastases tumor.

Zhang, Yaoshuai; Li, Yongping; Han, Yuehua; Li, Min; Li, Xian; Fan, Fangtian; Liu, Hao; Li, Shanshan

Zhang, Yaoshuai; Li, Yongping; Han, Yuehua; Li, Min; Li, Xian; Fan, Fangtian; Liu, Hao; Li, Shanshan.

Afiliação

Zhang Y; School of Pharmacy, Bengbu Medical College, Bengbu, China.
Li Y; School of Pharmacy, Bengbu Medical College, Bengbu, China.
Han Y; School of Pharmacy, Bengbu Medical College, Bengbu, China.
Li M; School of Pharmacy, Bengbu Medical College, Bengbu, China; Anhui Province Engineering Technology Research Center of Biochemical Pharmaceutical, Bengbu, China.
Li X; School of Pharmacy, Bengbu Medical College, Bengbu, China; Anhui Province Engineering Technology Research Center of Biochemical Pharmaceutical, Bengbu, China.
Fan F; School of Pharmacy, Bengbu Medical College, Bengbu, China; Anhui Province Engineering Technology Research Center of Biochemical Pharmaceutical, Bengbu, China.
Liu H; School of Pharmacy, Bengbu Medical College, Bengbu, China; Anhui Province Engineering Technology Research Center of Biochemical Pharmaceutical, Bengbu, China. Electronic address: liuhao6886@foxmail.com.
Li S; School of Pharmacy, Bengbu Medical College, Bengbu, China; Anhui Province Engineering Technology Research Center of Biochemical Pharmaceutical, Bengbu, China. Electronic address: Lishanshan900122@163.com.

Eur J Pharmacol ; 945: 175571, 2023 Apr 15.

Article em En | MEDLINE | ID: mdl-36804545

Assuntos

Neoplasias Encefálicas; Carcinoma Pulmonar de Células não Pequenas; Neoplasias Pulmonares; Camundongos; Animais; Humanos; Carcinoma Pulmonar de Células não Pequenas/patologia; Neoplasias Pulmonares/tratamento farmacológico; Camundongos Nus; Resistencia a Medicamentos Antineoplásicos; Linhagem Celular Tumoral; Receptores ErbB/metabolismo; Neoplasias Encefálicas/tratamento farmacológico; Neoplasias Encefálicas/genética; Encéfalo/metabolismo; Radiação Ionizante; Inibidores de Proteínas Quinases/farmacologia; Inibidores de Proteínas Quinases/uso terapêutico; Mutação

Palavras-chave

Aumolertinib; Brain metastases; Epidermal growth factor receptor-tyrosine kinase inhibitor; Ionizing radiation; Non-small cell lung cancer

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Carcinoma Pulmonar de Células não Pequenas / Neoplasias Pulmonares Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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