DOCK2 regulates MRGPRX2/B2-mediated mast cell degranulation and drug-induced anaphylaxis.

Kunimura, Kazufumi; Akiyoshi, Sayaka; Uruno, Takehito; Matsubara, Keisuke; Sakata, Daiji; Morino, Kenji; Hirotani, Kenichiro; Fukui, Yoshinori

Kunimura, Kazufumi; Akiyoshi, Sayaka; Uruno, Takehito; Matsubara, Keisuke; Sakata, Daiji; Morino, Kenji; Hirotani, Kenichiro; Fukui, Yoshinori.

Afiliação

Kunimura K; Department of Immunobiology and Neuroscience, Division of Immunogenetics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan. Electronic address: kunimura@bioreg.kyushu-u.ac.jp.
Akiyoshi S; Department of Immunobiology and Neuroscience, Division of Immunogenetics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
Uruno T; Department of Immunobiology and Neuroscience, Division of Immunogenetics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
Matsubara K; Department of Immunobiology and Neuroscience, Division of Immunogenetics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
Sakata D; Department of Immunobiology and Neuroscience, Division of Immunogenetics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
Morino K; Department of Immunobiology and Neuroscience, Division of Immunogenetics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
Hirotani K; Department of Immunobiology and Neuroscience, Division of Immunogenetics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
Fukui Y; Department of Immunobiology and Neuroscience, Division of Immunogenetics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.

J Allergy Clin Immunol ; 151(6): 1585-1594.e9, 2023 06.

Article em En | MEDLINE | ID: mdl-36804596

Assuntos

Anafilaxia; Hipersensibilidade a Drogas; Humanos; Camundongos; Animais; Anafilaxia/induzido quimicamente; Degranulação Celular; Mastócitos/metabolismo; Receptores de Neuropeptídeos/genética; Receptores de Neuropeptídeos/metabolismo; Hipersensibilidade a Drogas/metabolismo; Receptores Acoplados a Proteínas G/genética; Receptores Acoplados a Proteínas G/metabolismo; Fatores de Troca do Nucleotídeo Guanina/genética; Fatores de Troca do Nucleotídeo Guanina/metabolismo; Proteínas Ativadoras de GTPase/metabolismo; Proteínas do Tecido Nervoso/genética; Proteínas do Tecido Nervoso/metabolismo

Palavras-chave

DOCK2; Drug-induced anaphylaxis; MRGPRB2; MRGPRX2; PAK1; Rac; mast cell; phosphorylation; secretory granules

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hipersensibilidade a Drogas / Anafilaxia Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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