Methylmercury-induced reactive oxygen species-dependent and independent dysregulation of MAP kinase-related signaling pathway in cultured normal rat cerebellar astrocytes.

Sasaki, Shoto; Negishi, Takayuki; Tsuzuki, Takamasa; Yukawa, Kazunori

Sasaki, Shoto; Negishi, Takayuki; Tsuzuki, Takamasa; Yukawa, Kazunori.

Afiliação

Sasaki S; Department of Physiology, Graduate School of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku-ku, Nagoya-shi, Aichi 468-8503, Japan.
Negishi T; Department of Physiology, Graduate School of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku-ku, Nagoya-shi, Aichi 468-8503, Japan; Department of Physiology, Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku-ku, Nagoya-shi, Aichi 468-8503, Japan. Electronic address: tnegishi@meijo-u
Tsuzuki T; Department of Physiology, Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku-ku, Nagoya-shi, Aichi 468-8503, Japan.
Yukawa K; Department of Physiology, Graduate School of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku-ku, Nagoya-shi, Aichi 468-8503, Japan; Department of Physiology, Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku-ku, Nagoya-shi, Aichi 468-8503, Japan.

Toxicology ; 487: 153463, 2023 03 15.

Article em En | MEDLINE | ID: mdl-36813253

Assuntos

Antioxidantes; Compostos de Metilmercúrio; Ratos; Animais; Espécies Reativas de Oxigênio/metabolismo; Antioxidantes/farmacologia; Antioxidantes/metabolismo; Sistema de Sinalização das MAP Quinases; Astrócitos; Estresse Oxidativo; Glutationa/metabolismo; Acetilcisteína/farmacologia; Acetilcisteína/metabolismo; Células Cultivadas

Palavras-chave

Astrocytes; Glutathione; MAP kinases; Methylmercury; N-acetyl-L-cysteine; Oxidative stress

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Compostos de Metilmercúrio / Antioxidantes Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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