Protecting the kidney in sepsis: resident macrophages to the rescue.
Kidney Int
; 103(3): 461-463, 2023 03.
Article
em En
| MEDLINE
| ID: mdl-36822750
ABSTRACT
Kidney resident macrophages exert pro-inflammatory or reparative effects in experimental acute kidney injury, but their role in sepsis is unclear. In a mouse model of sepsis, Privratsky et al. show that kidney resident F4/80hi macrophages protect against kidney injury by expressing interleukin-1 receptor antagonist, which blocks interleukin-6 production selectively from endothelial cells. Discovery of this novel autocrine loop enhances opportunities for targeted therapies to diminish kidney injury during sepsis.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sepse
/
Injúria Renal Aguda
Limite:
Animals
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article