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Investigating CNS distribution of PF-05212377, a P-glycoprotein substrate, by translation of 5-HT6 receptor occupancy from non-human primates to humans.
Sawant-Basak, Aarti; Chen, Laigao; Lockwood, Peter; Boyden, Tracey; Doran, Angela C; Mancuso, Jessica; Zasadny, Kenneth; McCarthy, Timothy; Morris, Evan D; Carson, Richard E; Esterlis, Irina; Huang, Yiyun; Nabulsi, Nabeel; Planeta, Beata; Fullerton, Terence.
Afiliação
  • Sawant-Basak A; Clinical Pharmacology, Early Clinical Development, Worldwide Research, Development and Medical, Pfizer Inc, Cambridge, Massachusetts, USA.
  • Chen L; Digital Sciences and Translational Imaging, Early Clinical Development, Worldwide Research, Development and Medical, Pfizer Inc, Cambridge, Massachusetts, USA.
  • Lockwood P; Clinical Pharmacology, Early Clinical Development, Worldwide Research, Development and Medical, Pfizer Inc, Cambridge, Massachusetts, USA.
  • Boyden T; Pharmacokinetics, Dynamics, and Metabolism, Medicine Design, Worldwide Research, Development, and Medical, Pfizer Inc., Groton, Connecticut, USA.
  • Doran AC; Pharmacokinetics, Dynamics, and Metabolism, Medicine Design, Worldwide Research, Development, and Medical, Pfizer Inc., Groton, Connecticut, USA.
  • Mancuso J; Biostatistics, Early Clinical Development, Worldwide Research, Development and Medical, Pfizer Inc, Cambridge, Massachusetts, USA.
  • Zasadny K; Digital Sciences and Translational Imaging, Early Clinical Development, Worldwide Research, Development and Medical, Pfizer Inc, Cambridge, Massachusetts, USA.
  • McCarthy T; Digital Sciences and Translational Imaging, Early Clinical Development, Worldwide Research, Development and Medical, Pfizer Inc, Cambridge, Massachusetts, USA.
  • Morris ED; Department of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut, USA.
  • Carson RE; Department of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut, USA.
  • Esterlis I; Department of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut, USA.
  • Huang Y; Department of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut, USA.
  • Nabulsi N; Department of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut, USA.
  • Planeta B; Department of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut, USA.
  • Fullerton T; Internal Medicine, Global Product Development, Pfizer Inc, Groton, CT, USA.
Biopharm Drug Dispos ; 44(1): 48-59, 2023 Feb.
Article em En | MEDLINE | ID: mdl-36825693
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Encéfalo / Serotonina Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Encéfalo / Serotonina Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article