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Highly Recurrent IDH1 Mutations in Prostate Cancer With Psammomatous Calcification.
Mehra, Rohit; Shah, Tanmay; Liu, Chia-Jen; Plouffe, Komal R; Wang, Xiaoming; Mannan, Rahul; Cao, Xuhong; Chinnaiyan, Arul M; Tomlins, Scott A; Udager, Aaron M.
Afiliação
  • Mehra R; Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan; University of Michigan Rogel Cancer Center, Ann Arbor, Michigan; Michigan Center for Translational Pathology, Ann Arbor, Michigan.
  • Shah T; Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan.
  • Liu CJ; Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan.
  • Plouffe KR; Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan.
  • Wang X; Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan; Michigan Center for Translational Pathology, Ann Arbor, Michigan.
  • Mannan R; Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan; Michigan Center for Translational Pathology, Ann Arbor, Michigan.
  • Cao X; Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan; Michigan Center for Translational Pathology, Ann Arbor, Michigan.
  • Chinnaiyan AM; Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan; University of Michigan Rogel Cancer Center, Ann Arbor, Michigan; Michigan Center for Translational Pathology, Ann Arbor, Michigan; Department of Urology, University of Michigan Medical School, Ann Arbor, Michigan; H
  • Tomlins SA; Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan.
  • Udager AM; Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan; University of Michigan Rogel Cancer Center, Ann Arbor, Michigan; Michigan Center for Translational Pathology, Ann Arbor, Michigan. Electronic address: udager@umich.edu.
Mod Pathol ; 36(6): 100146, 2023 06.
Article em En | MEDLINE | ID: mdl-36828361
Prostate cancer is a heterogeneous disease with several well-recognized morphologic subtypes and histologic variants-subsets of which are enriched for or associated with specific genomic alterations. Herein, we report a cohort of 4 unique prostate cancers characterized by intratumoral psammomatous calcification-which we have termed prostate cancer with psammomatous calcification (PCWPC). Clinicopathologic review demonstrates that PCWPCs are high-grade (grade group ≥3) tumors that involve the anterior prostate, and integrative targeted next-generation sequencing reveals recurrent hotspot IDH1 mutations. This morphology-molecular correlation is independently confirmed in The Cancer Genome Atlas prostatic adenocarcinoma cohort, with 3 of the 5 IDH1-mutant prostate cancers showing psammomatous calcification (rφ = 0.67; Fisher exact test, P < .0001). Overall, these findings suggest that PCWPC represents a novel subtype of prostate cancer enriched for an anterior location and the presence of hotspot IDH1 mutations. Recognition of these unique morphologic features could help identify IDH1-mutant prostate cancer cases retrospectively and prospectively-facilitating future large research studies and enabling clinical trial enrollment and precision medicine approaches for patients with advanced and/or aggressive disease.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Calcinose / Neoplasias Meníngeas / Meningioma Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans / Male Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Calcinose / Neoplasias Meníngeas / Meningioma Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans / Male Idioma: En Ano de publicação: 2023 Tipo de documento: Article