Liver X Receptor Inverse Agonist GAC0001E5 Impedes Glutaminolysis and Disrupts Redox Homeostasis in Breast Cancer Cells.

Premaratne, Asitha; Ho, Charles; Basu, Shinjini; Khan, Ashfia Fatima; Bawa-Khalfe, Tasneem; Lin, Chin-Yo

Premaratne, Asitha; Ho, Charles; Basu, Shinjini; Khan, Ashfia Fatima; Bawa-Khalfe, Tasneem; Lin, Chin-Yo.

Afiliação

Premaratne A; Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, TX 77004, USA.
Ho C; Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, TX 77004, USA.
Basu S; Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, TX 77004, USA.
Khan AF; Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, TX 77004, USA.
Bawa-Khalfe T; Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, TX 77004, USA.
Lin CY; Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, TX 77004, USA.

Biomolecules ; 13(2)2023 02 10.

Article em En | MEDLINE | ID: mdl-36830714

Assuntos

Neoplasias da Mama; Receptores Nucleares Órfãos; Humanos; Feminino; Receptores X do Fígado/metabolismo; Receptores Nucleares Órfãos/metabolismo; Ligantes; Agonismo Inverso de Drogas; Glutamina/metabolismo; Homeostase; Oxirredução

Palavras-chave

breast cancer; glutaminolysis; ligands; liver X receptor; metabolism

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Receptores Nucleares Órfãos Tipo de estudo: Prognostic_studies Limite: Female / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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