Contribution of Fetal Inflammatory Response Syndrome (FIRS) with or without Maternal-Fetal Inflammation in The Placenta to Increased Risk of Respiratory and Other Complications in Preterm Neonates.
Biomedicines
; 11(2)2023 Feb 18.
Article
em En
| MEDLINE
| ID: mdl-36831147
ABSTRACT
This study classifies fetal inflammatory response syndrome (FIRS) based on the presence or absence of maternal-fetal inflammation in the placenta and clarifies the association of FIRS with neonatal morbidities. Women (330) who delivered at gestational ages of 22w0d-33w6d were enrolled and grouped into four based on FIRS and maternal/fetal inflammatory response (MIR/FIR) statuses Group A without FIRS and MIR/FIR (reference group); Group B MIR/FIR alone; Group C FIRS and MIR/FIR; and Group D FIRS without MIR/FIR. The associations between bronchopulmonary dysplasia (BPD), adverse neonatal outcomes, extremely low gestational age and Groups B, C, and D were investigated after adjustment for potential confounders. Among patients with FIRS, 29% were in Group D. The risk of BPD was increased in Groups C (adjusted odds ratio (aOR) 3.36; 95% confidence interval (CI) 1.14-9.89) and D (aOR 4.17; 95% CI 1.03-16.9), as was the risk of adverse neonatal outcomes (Group C aOR 7.17; 95% CI 2.56-20.1; Group D aOR 6.84; 95% CI 1.85-25.2). The risk of extremely low gestational age was increased in Group D (aOR 3.85; 95% CI 1.56-9.52). Therefore, FIRS without MIR/FIR is not rare and may be associated with neonatal morbidities more than FIRS and MIR/FIR.
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Base de dados:
MEDLINE
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article